34164-50-6Relevant articles and documents
Synthesis of functionalized polycarbosilanes via one-pot ADMET polymerization-macromolecular substitution
Church, A. Cameron,Pawlow, James H.,Wagener
, p. 5746 - 5751 (2002)
Three substituted unsaturated polycarbosilanes were prepared from the same parent using a two-step, one-pot ADMET polycondensation-nucleophilic substitution route. Condensation metathesis of di(4-pentenyl)dichlorosilane using Schrock's [Mo] catalyst produces a polymer backbone containing two reactive silicon-chlorine bonds per unit. Replacement of these bonds with stable alkyl moieties was performed using an excess of alkyllithium reagent without undesirable main chain alkylation or cross-linking. Upon functionalization, moisture-stable polymers were synthesized, indicating quantitative substitution was achieved. All of the resulting polymers are amorphous, elastomeric materials. Variation of the two pendant groups from phenyl to methyl resulted in a Tg change of over 85°C.
PIKFYVE KINASE INHIBITORS
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Page/Page column 263-264, (2021/08/20)
The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.
Controllable, Sequential, and Stereoselective C-H Allylic Alkylation of Alkenes
Qin, Ling,Sharique, Mohammed,Tambar, Uttam K.
supporting information, p. 17305 - 17313 (2019/11/03)
The direct conversion of C-H bonds into new C-C bonds represents a powerful approach to generate complex molecules from simple starting materials. However, a general and controllable method for the sequential conversion of a methyl group into a fully substituted carbon center remains a challenge. We report a new method for the selective and sequential replacement of three C-H bonds at the allylic position of propylene and other simple terminal alkenes with different carbon groups derived from Grignard reagents. A copper catalyst and electron-rich biaryl phosphine ligand facilitate the formation of allylic alkylation products in high branch selectivity. We also present conditions for the generation of enantioenriched allylic alkylation products in the presence of catalytic copper and a chiral phosphine ligand. With this approach, diverse and complex products with substituted carbon centers can be generated from simple and abundant feedstock chemicals.
MACROCYCLIC AND BICYCLIC INHIBITORS OF HEPATITIS C VIRUS
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Page/Page column 94, (2014/09/29)
Compounds of formula (I):or pharmaceutically acceptable salts thereof, wherein the various substituents are defined herein, methods of using said compounds, and pharmaceutical compositions containing said compounds.
