34183-22-7 Usage
Description
Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 34183-22-7 differently. You can refer to the following data:
1. Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
2. Sodium channel blocker. Antiarrhythmic (class IC)
Definition
ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Brand name
Rythmol (Reliant).
Pharmacokinetics
Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Clinical Use
Anti-arrhythmic agent:
Ventricular arrhythmias
Paroxysmal supraventricular tachyarrhythmias,
(including paroxysmal atrial flutter or fibrillation,
and paroxysmal re-entrant tachycardias involving
the AV node or accessory pathway) where standard
therapy has failed or is unsuitable
Drug interactions
Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased myocardial depression
with other anti-arrhythmics.
Antibacterials: increased metabolism with rifampicin
(reduced effect).
Anticoagulants: enhanced anticoagulant effect of
coumarins.
Antidepressants: increased risk of arrhythmias
with tricyclics; metabolism of propafenone possibly
inhibited by paroxetine (increased risk of toxicity).
Antihistamines: increased risk of ventricular
arrhythmias with mizolastine - avoid.
Antipsychotics: increased risk of ventricular
arrhythmias with antipsychotics that prolong the QT
interval.
Antivirals: concentration of propafenone increased
by saquinavir and ritonavir and possibly by
fosamprenavir, increased risk of ventricular
arrhythmias - avoid; use with caution with
telaprevir.
Beta-blockers: increased myocardial depression;
increased concentration of metoprolol and
propranolol.
Cardiac glycosides: increased digoxin concentration -
halve digoxin dose.
Ciclosporin: possibly increased ciclosporin
concentration.
Ulcer-healing drugs: levels increased by cimetidine.
Metabolism
Propafenone is hepatically metabolised mainly by
CYP2D6 isoenzyme but also to a small extent by
CYP1A2 and CYP3A4. This forms 2 active metabolites,
5-hydroxypropafenone and N-depropylpropafenone and
some inactive ones. Propafenone and its metabolites also
undergo glucuronidation. The extent of metabolism is
genetically determined.
Propafenone is excreted in the urine and faeces mainly in
the form of conjugated metabolites.
Check Digit Verification of cas no
The CAS Registry Mumber 34183-22-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,1,8 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 34183-22:
(7*3)+(6*4)+(5*1)+(4*8)+(3*3)+(2*2)+(1*2)=97
97 % 10 = 7
So 34183-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H27NO3.ClH/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17;/h3-11,18,22-23H,2,12-16H2,1H3;1H
34183-22-7Relevant articles and documents
Chemoselective Hydrosilylation of the α,β-Site Double Bond in α,β- And α,β,γ,δ-Unsaturated Ketones Catalyzed by Macrosteric Borane Promoted by Hexafluoro-2-propanol
Zhan, Xiao-Yu,Zhang, Hua,Dong, Yu,Yang, Jian,He, Shuai,Shi, Zhi-Chuan,Tang, Lei,Wang, Ji-Yu
, p. 6578 - 6592 (2020/07/17)
The B(C6F5)3-catalyzed chemoselective hydrosilylation of α,β- and α,β,γ,δ-unsaturated ketones into the corresponding non-symmetric ketones in mild reaction conditions is developed. Nearly 55 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylated in good to excellent yields. Isotope-labeling studies revealed that hexafluoro-2-propanol also served as a hydrogen source in the process.
Preparation of propafenone
-
, (2008/06/13)
A process for the preparation of propafenone wherein 1. 2'-hydroxyacetophenone is reacted with epichlorohydrin, 2. the resulting 2-(2',3'-epoxypropoxy)-acetophenone is reacted with propylamine, 3. the resulting 2-(2'-hydroxy-3'-propylaminopropoxy)-acetophenone is reacted with benzaldehyde, accompanied by elimination of water, and 4. the resulting 2-(2'-hydroxy-3'-propylaminopropoxy)-benzalacetophenone is hydrogenated.
