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34183-22-7

34183-22-7

Identification

  • Product Name:1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1)

  • CAS Number: 34183-22-7

  • EINECS:251-867-9

  • Molecular Weight:377.911

  • Molecular Formula: C21H28ClNO3

  • HS Code:2922504500

  • Mol File:34183-22-7.mol

Synonyms:1-Propanone,1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);Propiophenone, 2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-, hydrochloride(8CI);Arythmol;Pronon;Rythmol;Rytmonorm;

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Safety information and MSDS view more

  • Pictogram(s):ToxicT, HarmfulXn

  • Hazard Codes:T,Xn

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowed

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:Propafenone hydrochloride
  • Packaging:250mg
  • Price:$ 215
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:Propafenone Hydrochloride >98.0%(HPLC)(T)
  • Packaging:1g
  • Price:$ 27
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propafenone hydrochloride
  • Packaging:5g
  • Price:$ 122
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propafenonehydrochloridesolution 1?mg/mLinmethanol((asfreebase)),certifiedreferencematerial,ampuleof1?
  • Packaging:1ML
  • Price:$ 69
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propafenone hydrochloride European Pharmacopoeia (EP) Reference Standard
  • Packaging:
  • Price:$ 190
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propafenone hydrochloride European Pharmacopoeia (EP) Reference Standard
  • Packaging:y0000455
  • Price:$ 190
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propafenone hydrochloride United States Pharmacopeia (USP) Reference Standard
  • Packaging:200mg
  • Price:$ 366
  • Delivery:In stock
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  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:Propafenone-d5hydrochloride(propoxy-d5)
  • Packaging:5 mg
  • Price:$ 1190
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:Propafenone hydrochloride 97%
  • Packaging:100g
  • Price:$ 238
  • Delivery:In stock
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  • Manufacture/Brand:ChemScene
  • Product Description:Propafenone hydrochloride 99.55%
  • Packaging:1g
  • Price:$ 60
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Relevant articles and documentsAll total 3 Articles be found

Chemoselective Hydrosilylation of the α,β-Site Double Bond in α,β- And α,β,γ,δ-Unsaturated Ketones Catalyzed by Macrosteric Borane Promoted by Hexafluoro-2-propanol

Zhan, Xiao-Yu,Zhang, Hua,Dong, Yu,Yang, Jian,He, Shuai,Shi, Zhi-Chuan,Tang, Lei,Wang, Ji-Yu

, p. 6578 - 6592 (2020/07/17)

The B(C6F5)3-catalyzed chemoselective hydrosilylation of α,β- and α,β,γ,δ-unsaturated ketones into the corresponding non-symmetric ketones in mild reaction conditions is developed. Nearly 55 substrates including those bearing reducible functional groups such as alkynyl, alkenyl, cyano, and aromatic heterocycles are chemoselectively hydrosilylated in good to excellent yields. Isotope-labeling studies revealed that hexafluoro-2-propanol also served as a hydrogen source in the process.

Preparation methods of propafenone hydrochloride and intermediate 2'-hydroxydihydrochalcone thereof

-

, (2020/06/17)

The invention discloses preparation methods of propafenone hydrochloride and an intermediate 2'-hydroxydihydrochalcone thereof. 2-phenyl-benzothiazoline is adopted as a reducing agent to construct a reduction system, carbon-carbon double bonds are reduced, double bonds in a substrate can be efficiently and selectively reduced, and the problem that the propafenone hydrochloride key intermediate 2'-hydroxydihydrochalcone is synthesized by using hydrogen is avoided. The used reducing agent is simple and easily available, and the preparation methods have the advantages of low requirements on reaction equipment and operation, suitableness for industrial production, no hydrogen and noble metals, safety and environmental friendliness.

Preparation of propafenone

-

, (2008/06/13)

A process for the preparation of propafenone wherein 1. 2'-hydroxyacetophenone is reacted with epichlorohydrin, 2. the resulting 2-(2',3'-epoxypropoxy)-acetophenone is reacted with propylamine, 3. the resulting 2-(2'-hydroxy-3'-propylaminopropoxy)-acetophenone is reacted with benzaldehyde, accompanied by elimination of water, and 4. the resulting 2-(2'-hydroxy-3'-propylaminopropoxy)-benzalacetophenone is hydrogenated.

Process route upstream and downstream products

Process route

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one
22525-95-7

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
propylamine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one; for 4h; Reflux;
With hydrogenchloride; In water; for 1h; Reflux;
85%
propylamine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one; at 20 - 50 ℃; for 6h;
With hydrogenchloride; for 1h; Reflux;
74.5%
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
1214-47-7

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: 2-Phenylbenzothiazolin; aluminum (III) chloride / toluene / 2 h / 110 °C
1.2: 6 h / 20 - 25 °C
2.1: 8 h / 110 °C
3.1: 6 h / 20 - 50 °C
3.2: 1 h / Reflux
With aluminum (III) chloride; 2-Phenylbenzothiazolin; In toluene;
Multi-step reaction with 3 steps
1.1: tris(pentafluorophenyl)borate; triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol / 1 h / 40 °C
2.1: 4 h / Reflux
3.1: 4 h / Reflux
3.2: 1 h / Reflux
With triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol; tris(pentafluorophenyl)borate;
1-(2-(allyloxy)phenyl)-3-phenylpropan-1-one

1-(2-(allyloxy)phenyl)-3-phenylpropan-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C
2.1: 4 h / Reflux
2.2: 1 h / Reflux
With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
2'-allyloxychalcone
16619-51-5

2'-allyloxychalcone

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: tris(pentafluorophenyl)borate; triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol / 1 h / 40 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C
3.1: 4 h / Reflux
3.2: 1 h / Reflux
With triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol; tris(pentafluorophenyl)borate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
2'-hydroxydihydrochalcone sodium

2'-hydroxydihydrochalcone sodium

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: 8 h / 110 °C
2.1: 6 h / 20 - 50 °C
2.2: 1 h / Reflux
2'-hydroxy-3-phenylpropiophenone
3516-95-8

2'-hydroxy-3-phenylpropiophenone

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: 4 h / Reflux
2.1: 4 h / Reflux
2.2: 1 h / Reflux
propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one
22525-95-7

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
propylamine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one; for 4h; Reflux;
With hydrogenchloride; In water; for 1h; Reflux;
85%
propylamine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one; at 20 - 50 ℃; for 6h;
With hydrogenchloride; for 1h; Reflux;
74.5%
1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one
1214-47-7

1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: 2-Phenylbenzothiazolin; aluminum (III) chloride / toluene / 2 h / 110 °C
1.2: 6 h / 20 - 25 °C
2.1: 8 h / 110 °C
3.1: 6 h / 20 - 50 °C
3.2: 1 h / Reflux
With aluminum (III) chloride; 2-Phenylbenzothiazolin; In toluene;
Multi-step reaction with 3 steps
1.1: tris(pentafluorophenyl)borate; triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol / 1 h / 40 °C
2.1: 4 h / Reflux
3.1: 4 h / Reflux
3.2: 1 h / Reflux
With triethylsilane; 1,1,1,3',3',3'-hexafluoro-propanol; tris(pentafluorophenyl)borate;
1-(2-(allyloxy)phenyl)-3-phenylpropan-1-one

1-(2-(allyloxy)phenyl)-3-phenylpropan-1-one

propafenone hydrochloride
34183-22-7

propafenone hydrochloride

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C
2.1: 4 h / Reflux
2.2: 1 h / Reflux
With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

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  • Chemwill Asia Co., Ltd.
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