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342808-41-7

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342808-41-7 Usage

General Description

4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-, acetate is a chemical compound that consists of a piperidinone ring with two fluorophenylmethylene groups and an acetate group attached. It is often used in organic synthesis as a building block for other compounds. The presence of the fluorophenylmethylene groups makes this compound useful in the development of pharmaceuticals and agrochemicals. Additionally, the acetate group adds to its versatility as a reagent in chemical reactions. 4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-, acetate may also have potential applications in the field of materials science and as a chemical intermediate in various industries. Overall, 4-Piperidinone, 3,5-bis[(2-fluorophenyl)methylene]-, acetate is a versatile and important chemical compound with a range of potential uses.

Check Digit Verification of cas no

The CAS Registry Mumber 342808-41-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,2,8,0 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 342808-41:
(8*3)+(7*4)+(6*2)+(5*8)+(4*0)+(3*8)+(2*4)+(1*1)=137
137 % 10 = 7
So 342808-41-7 is a valid CAS Registry Number.

342808-41-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name acetic acid,3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:342808-41-7 SDS

342808-41-7Relevant articles and documents

Anticancer Activity of an Imageable Curcuminoid 1-[2-Aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH)

Lagisetty, Pallavi,Subramaniam, Dharmalingam,Sahoo, Kaustuv,Anant, Shrikant,Awasthi, Vibhudutta

, p. 194 - 201 (2012)

3,5-Bis(2-fluorobenzylidine)-4-piperidone or EF24 is a potent anticancer derivative of curcumin. Using an amine derivative of EF24, we synthesized a hydrazinonicotinic acid conjugate, EFAH, for Tc-99m radiolabelling and single photon emission tomography imaging. The aqueous solubility of EFAH (3.5mg/mL) was significantly more than that of EF24 (1.2mg/mL); the octanol/water partition coefficient of EFAH was estimated at log P=0.33. As an antiproliferative agent, EFAH was as effective as EF24 in suppressing the proliferation of H441, MiaPaCa-2 and Panc-1 cells. Daily intraperitoneal injection of EFAH (5μg) for 3weeks in mice carrying xenografts of Panc-1 pancreatic cancer showed a mean tumour volume reduction of 79%; the tumour weight decreased by 82% in the treated group. For imaging and biodistribution, EFAH was labelled with Tc-99m (98% RCY) and intravenously administered in rats. Approximately 23.7% and 14.3% of injected dose accumulated in liver and intestine, respectively, suggesting that EFAH is mostly eliminated by hepatobiliary route. The results indicate that HYNIC modification of EF24 for Tc-99m radiolabelling does not affect its antiproliferative efficacy. For the first time, a visual biodisposition of EF24 in a live animal model has been demonstrated. Such knowledge could be of benefit in developing therapeutic curcuminoids, such as EF24.

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