34290-72-7Relevant articles and documents
N-Terminal Selective C?H Azidation of Proline-Containing Peptides: a Platform for Late-Stage Diversification
Allouche, Emmanuelle M. D.,Simonet-Davin, Rapha?l,Waser, Jerome
supporting information, (2022/02/25)
A methodology for the C?H azidation of N-terminal proline-containing peptides was developed employing only commercially available reagents. Peptides bearing a broad range of functionalities and containing up to 6 amino acids were selectively azidated at the carbamate-protected N-terminal residue in presence of the numerous other functional groups present on the molecules. Post-functionalizations of the obtained aminal compounds were achieved: cycloaddition reactions or C?C bond formations via a sequence of imine formation/nucleophilic addition were performed, offering an easy access to diversified peptides.
A bio-inspired approach to proline-derived 2,4-disubstituted oxazoles
Slobodyanyuk, Evgeniy Y.,Artamonov, Oleksiy S.,Kulik, Irene B.,Rusanov, Eduard,Volochnyuk, Dmitriy M.,Grygorenko, Oleksandr O.
, p. 11 - 17 (2018/02/06)
A convenient four-step approach to the synthesis of (S)-4-alkyl-2-(pyrrolidin-2-yl)oxazoles starting from l-Boc-proline inspired by naturally occurring oxazole-containing peptidomimetics is described. The key step is the cyclization of 1-Boc-N-(1-oxoalkan
Aggregation propensity of amyloidogenic and elastomeric dipeptides constituents
Kumar, Vikas,Krishna, K. Vijaya,Khanna, Shruti,Joshi, Khashti Ballabh
, p. 5369 - 5376 (2016/08/05)
This study demonstrates the self-assembly of N- and C-terminal protected dipeptides Phe–Gly and Pro–Gly which were derived from amyloidogenic and elastomeric peptide sequences. These constituents afforded nanostructured supramolecular ensembles through va