343-26-0

Basic information

• Product Name: 6-fluoro-8-nitroquinoline
• Synonyms: 6-fluoro-8-nitroquinoline
• CAS NO: 343-26-0
• Molecular Formula: C9H5FN2O2
• Molecular Weight: 192.15
• Mol File: 343-26-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 327°Cat760mmHg
• Flash Point: 151.6°C
• Appearance: /
• Density: 1.446g/cm³
• Vapor Pressure: 0.000396mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 6-fluoro-8-nitroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-8-nitroquinoline(343-26-0)
• EPA Substance Registry System: 6-fluoro-8-nitroquinoline(343-26-0)

Safety Data

• Hazardous Substances Data: 343-26-0(Hazardous Substances Data)

Usage

Uses

6-Fluoro-8-nitroquinoline is an intermediate in synthesizing 6-Fluoro-8-Quinolinesulfonyl Chloride (F596550), which is may act as a clastogenic compound as well as inhibitor of CYP enzymes due to the quinoline moiety in the substructure.

InChI:InChI=1/C9H5FN2O2/c10-7-4-6-2-1-3-11-9(6)8(5-7)12(13)14/h1-5H

Upstream product

• 100-02-7 4-nitro-phenol 
• 364-78-3 2-nitro-4-fluoroaniline 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 
• 351-83-7 4'-fluoroacetanilide 
• 394-70-7 4-Fluoroquinoline 
• 56-81-5 glycerol 
• 396-30-5 6-fluoroquinoline 

Downstream Products

• 343-54-4 8-amino-6-fluoroquinoline 
• 575-21-3 N-(6-fluoro-[8]quinolyl)-anthranilic acid 
• 442-65-9 4-fluoro-benzenesulfonic acid-(6-fluoro-[8]quinolylamide) 
• 515170-53-3 8-amino-3-bromo-6-fluoroquinoline 
• 515170-52-2 8-amino-3-chloro-6-fluoroquinoline 
• 515170-51-1 3-bromo-6-fluoro-8-nitroquinoline 

Relevant articles and documents

Visible Light-Promoted Photocatalytic C-5 Carboxylation of 8-Aminoquinoline Amides and Sulfonamides via a Single Electron Transfer Pathway

An efficient photocatalytic method was developed for the remote C5-H bond carboxylation of 8-aminoquinoline amide and sulfonamide derivatives. This methodology uses in situ generated ?CBr3 radical as a carboxylation agent with alcohol and is further extended to a variety of arenes and heteroarenes to synthesize the desired carboxylated product in moderate-to-good yields. The reaction proceeding through a single electron transfer pathway was established by a control experiment, and a butylated hydroxytoluene-trapped aryl radical cation intermediate in high-resolution mass spectrometry was identified.

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

Compounds of general formula I: and compositions comprising compounds of general formula I that modulate pyruvate kinase are described herein. Also described herein are methods of using the compounds that modulate pyruvate kinase in the treatment of diseases.

Novel Sulfonaminoquinoline Hepcidin Antagonists

The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.