344-20-7

Basic information

• Product Name: 2,6-DIBROMO-4-FLUOROPHENOL
• Synonyms: 2,6-Dibromo-4-2-fluorophenol;2,6-DIBROMO-4-FLUOROPHENOL;1-Bromo-3,4,5-trifluorobezene;2,6-Dibromo-4-fluorophenol 97%;2,6-Dibromo-4-fluorophenol97%;2,6-Dibromo-4-fluorophenol, 98+%;4-Fluoro-2,6-dibromophenol
• CAS NO: 344-20-7
• Molecular Formula: C₆H₃Br₂FO
• Molecular Weight: 269.89
• EINECS: 206-451-1
• Product Categories: Phenol&Thiophenol&Mercaptan;Bromine Compounds;Fluorine Compounds;Phenols;Organic Building Blocks;Oxygen Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C6;C6 to C8;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Oxygen Compounds
• Mol File: 344-20-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 55-57°C
• Boiling Point: 219.5 °C at 760 mmHg
• Flash Point: 86.5 °C
• Appearance: white to light yellow crystal powder
• Density: 2.168 g/cm³
• Vapor Pressure: 0.0807mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Methanol
• PKA: 6.92±0.23(Predicted)
• BRN: 1868033
• CAS DataBase Reference: 2,6-DIBROMO-4-FLUOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DIBROMO-4-FLUOROPHENOL(344-20-7)
• EPA Substance Registry System: 2,6-DIBROMO-4-FLUOROPHENOL(344-20-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37-36-26
• Hazardous Substances Data: 344-20-7(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C6H3Br2FO/c7-4-1-3(9)2-5(8)6(4)10/h1-2,10H

Upstream product

• 371-41-5 4-Fluorophenol 
• 74-88-4 methyl iodide 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 19643-45-9 2,6-dibromo-1,4-benzoquinone 
• 320-75-2 2-bromo-4-fluoro-6-nitrophenol 
• 319-50-6 (2,6-dibromo-4-fluoro-phenoxy)-acetic acid 
• 443-41-4 1,3-dibromo-5-fluoro-2-methoxybenzene 
• 346664-78-6 1,3-dibromo-5-fluoro-2-methoxy-4-nitro-benzene 
• 1265218-50-5 2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide 
• 1265218-38-9 2,4-dibromo-6-fluoro-3-methoxyaniline 
• 1265218-40-3 N-(2,4-dibromo-6-fluoro-3-methoxyphenyl)acetamide 
• 117923-66-7 2,6-dibromo-4-fluorphenyl phenyl ether 
• 117923-79-2 C₆⁽¹³⁾CH₅Br₂FO 
• 1051899-78-5 2-chloro-N-(2-fluoro-5-methoxyphenyl)pyrimidin-4-amine 
• 62257-15-2 2-fluoro-5-methoxyaniline 

Relevant articles and documents

Method for photocatalytic synthesis of polybrominated phenol compound in water phase

The invention discloses a method for photocatalytic synthesis of a polybrominated phenol compound in a water phase, comprising the following steps: adding a catalytic amount of a radical initiator, aphenol derivative and low-toxic and cheap bromide salt and water into a reaction vessel, reacting at room temperature at 5 W power in a photocatalytic reactor for a certain period, extracting with ethyl acetate and then re-crystallizing to obtain a polybrominated phenol compound. The above radical initiator is eosin, azobisisobutanol, sodium persulfate, ammonium persulfate or potassium persulfate.The free radical initiator and the bromine salt are cheap and easily available, and the method is an ideal synthesis method of the polybrominated phenol compound. According to the method, low-toxicity bromine salt instead of liquid bromine is used to carry out a bromination reaction, unstable and explosive hydrogen peroxide is replaced with the cheap and easily-available free radical initiator, and an emerging photocatalytic method is used. The polybrominated phenol compound can be obtained in a high yield by only using a 5W power lamp for the reaction, the reaction selectivity is high, by-products are less, and the post-treatment is simple.

Selective and efficient generation of ortho-brominated para-substituted phenols in ACS-grade methanol

The mono ortho-bromination of phenolic building blocks by NBS has been achieved in short reaction times (15-20 min) using ACS-grade methanol as a solvent. The reactions can be conducted on phenol, naphthol and biphenol substrates, giving yields of >86% on gram scale. Excellent selectivity for the desired mono ortho-brominated products is achieved in the presence of 10 mol % para-TsOH, and the reaction is shown to be tolerant of a range of substituents, including CH3/ F,and NHBoc.

COMPOUNDS AND METHODS OF USE THEREOF

Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.