34486-06-1

Basic information

• Product Name: 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE
• Synonyms: 6-TRIFLUOROMETHYLPYRIDIN-2-ONE;2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE;2-HYDROXY-6-TRIFLUOROMETHYLPRIDINE;6-TRIFLUOROMETHYL-PYRIDINE-2-OL;6-trifluoromethyl-1H-pyridin-2-one;2(1H)-Pyridinone, 6-(trifluoromethyl)-;2-Hydroxy-6-trifluoromethylpyridine 6-Trifluoromethyl-1H-pyridin-2-one;2-Hydroxy-6-(trifloromethyl)pyridine
• CAS NO: 34486-06-1
• Molecular Formula: C₆H₄F₃NO
• Molecular Weight: 163.1
• EINECS: 1308068-626-2
• Product Categories: Building Blocks;C6 to C7;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis;Pyridines;Fluorine series;alcohol
• Mol File: 34486-06-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 223.749 °C at 760 mmHg
• Flash Point: 89.12 °C
• Appearance: White powder
• Density: 1.398 g/cm³
• Vapor Pressure: 0.095mmHg at 25°C
• Refractive Index: 1.437
• Storage Temp.: Room temperature.
• PKA: 8.03±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE(34486-06-1)
• EPA Substance Registry System: 2-HYDROXY-6-(TRIFLUOROMETHYL)PYRIDINE(34486-06-1)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38-36-25
• Safety Statements: 26-36/37/39-45
• RIDADR: 2811
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 34486-06-1(Hazardous Substances Data)

Usage

Uses

2-Hydroxy-6-trifluoromethylpyridine

InChI:InChI=1/C6H4F3NO/c7-6(8,9)4-2-1-3-5(11)10-4/h1-3H,(H,10,11)

Upstream product

• 1119-40-0 Dimethyl glutarate 
• 1161004-61-0 methyl 6,6,6-trifluoro-5-oxohexanoate 
• 184157-07-1 6-Trifluoromethyl-3,4-dihydro-1H-pyridin-2-one 
• 818-38-2 Diethyl glutarate 
• 94239-04-0 2-fluoro-6-(trifluoromethyl)pyridine 
• 39890-95-4 2-chloro-6-trifluoromethylpyridine 
• 7664-93-9 sulfuric acid 
• 19621-92-2 2-oxo-1,2-dihydropyridine-6-carboxylic acid 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 

Downstream Products

• 34486-18-5 2-methoxy-6-(trifluoromethyl)pyridine 
• 1429874-11-2 [2-methoxy-6-(trifluoromethyl)pyridin-3-yl]boronic acid 
• 117428-22-5 picoxystrobin 
• 1346541-01-2 2-(tert-butyl)-6-(trifluoromethyl)pyridine 
• 117519-12-7 6-chloro-3-nitro-2-(trifluoromethyl)pyridine 
• 117519-08-1 2-chloro-3-nitro-6-(trifluoromethyl)pyridine 
• 117519-07-0 3-nitro-6-(trifluoromethyl)pyridin-2-ol 
• 187327-30-6 2-[6-(trifluoromethyl)-2-pyridyloxymethyl]phenylacetic acid methyl ester 

Relevant articles and documents

Preparation method of 2-hydroxy-6-trifluoromethylpyridine

The invention provides a preparation method of 2-hydroxy-6-trifluoromethylpyridine. The method comprises the following steps of: carrying out Grignard reaction on trifluorohalomethane and magnesium powder to prepare a Grignard reagent; reacting the obtained Grignard reagent with 1, 5-glutaric acid diester, and then acidifying to obtain 4-trifluoroacetyl butyrate; then, carrying out cyclization reaction on the 4-trifluoroacetyl butyrate and ammonia to obtain 6-trifluoromethyl-3, 4-dihydropyridine-2-ketone; and then carrying out an oxidation reaction to obtain the 2-hydroxy-6-trifluoromethylpyridine. The raw materials used in the method are cheap, easy to obtain and low in cost; the steps are simple, and the target product can be prepared by only two steps; the operation is simple and easy for industrial operation; reaction conditions are mild and easy to realize; less wastewater is generated, and the method is green, safe and environment-friendly; and the related raw materials and intermediate products are stable, the reaction selectivity is high, byproducts are few, the yield and purity of the target product are high, and the method is suitable for industrial production.

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

IMIDAZO [1,5-A] PYRAZINE DERIVATIVES AS PI3Kdelta INHIBITORS

Disclosed is a compound of Formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions comprising thereof. Also disclosed is a method of treating PI3Kδ related disorders or diseases by using the c