34645-72-2

Basic information

• Product Name: Benzeneacetic acid, 4-iodo-α-Methyl
• Synonyms: Benzeneacetic acid, 4-iodo-α-Methyl;Ethyl 2-(4-iodophenyl)propanoate;2-(4-iodophenyl)propanoic acid
• CAS NO: 34645-72-2
• Molecular Formula: C₉H₉IO₂
• Molecular Weight: 304.12419
• EINECS: -0
• Mol File: 34645-72-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 187-190 °C
• Boiling Point: 333.2±25.0 °C(Predicted)
• Appearance: /
• Density: 1.767±0.06 g/cm3(Predicted)
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: Benzeneacetic acid, 4-iodo-α-Methyl(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 4-iodo-α-Methyl(34645-72-2)
• EPA Substance Registry System: Benzeneacetic acid, 4-iodo-α-Methyl(34645-72-2)

Safety Data

• Hazardous Substances Data: 34645-72-2(Hazardous Substances Data)

Upstream product

• 7758-19-2 sodium chlorite 
• 70991-79-6 4-iodo-α-methylbenzeneacetaldehyde 
• 5329-14-6 aminosulfonic acid 
• 41073-25-0 2-(4-iodo-phenyl)-propionic acid methyl ester 
• 350-46-9 4-Fluoronitrobenzene 
• 61881-50-3 amino-4-phenyl methyl malonate d'ethyle 
• 61881-49-0 Diethyl 2-methyl-2-(4-nitrophenyl)malonate 

Downstream Products

• 6341-72-6 2-(4-biphenylyl)propanoic acid 
• 76099-91-7 (S)-(+)-2-(4'-iodophenyl)propanoic acid 
• 152140-57-3 (R)-2-(4-iodophenyl)propanoic acid 
• 1364766-12-0 N-ethyl-2-(4-iodo-phenyl)-propionamide 
• 1364758-95-1 N-Ethyl-2-[4-(2-isopropylamino-pyrimidin-5-ylethynyl)-phenyl]-propionamide 
• 1364759-90-9 N-Ethyl-2-{4-[2-(2-fluoro-ethoxy)-pyrimidin-5-ylethynyl]-phenyl}-propionamide 
• 1364760-13-3 N-Ethyl-2-[4-(4-methoxy-phenylethynyl)-phenyl]-propionamide 
• 1364763-08-5 N-Ethyl-2-[4-(4-isopropyl-phenylethynyl)-phenyl]-propionamide 
• 1364767-24-7 N-ethyl-2-(4-trimethylsilanylethynyl-phenyl)-propionamide 
• 1364767-30-5 N-ethyl-2-(4-ethynyl-phenyl)-propionamide 
• 1364767-36-1 2-[4-(2-chloro-pyrimidin-5-ylethynyl)-phenyl]-N-ethyl-propionamide 
• 1441255-95-3 2-(4-{1 [2-(cyclopentyl-methyl-amino)-pyrimidin-4-yl]-piperidin-4-yl}-phenyl)-N-ethyl-propionamide 
• 1441257-09-5 N-ethyl-2-(4-piperidin-4-yl-phenyl)-propionamide 
• 1441257-06-2 N-ethyl-2-(4-pyridin-4-yl-phenyl)-propionamide 

Relevant articles and documents

PIPERIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The invention relates to new piperidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

ETHYNE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

invention relates to new compounds of the formula I to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them

Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of β-amyloid1-42 secretion

Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit β-amyloid1-42 (Aβ42) secretion, the most toxic component of the senile plaques present in the brain of Alzheimer patients. The use of this NSAID in Alzheimer's disease (AD) is hampered by a significant gastrointestinal toxicity associated with cyclooxygenase (COX) inhibition. New flurbiprofen analogues were synthesized, with the aim of increasing Aβ42 inhibitory potency while removing anti-COX activity. In vitro ADME developability parameters were taken into account in order to identify optimized compounds at an early stage of the project. Appropriate substitution patterns at the alpha position of flurbiprofen allowed for the complete removal of anti-COX activity, while modifications at the terminal phenyl ring resulted in increased inhibitory potency on Aβ42 secretion. In rats, some of the compounds appeared to be well absorbed after oral administration and to penetrate into the central nervous system. Studies in a transgenic mice model of AD showed that selected compounds significantly decreased plasma Aβ42 concentrations. These new flurbiprofen analogues represent potential drug candidates to be developed for the treatment of AD.