34881-45-3Relevant articles and documents
Zwitterionic-Salt-Catalyzed Site-Selective Monobromination of Arenes
Xiong, Xiaodong,Tan, Fei,Yeung, Ying-Yeung
supporting information, p. 4243 - 4246 (2017/08/23)
A zwitterionic-salt-catalyzed electrophilic monobromination of arenes with high regioselectivity has been developed. Under mild reaction conditions, a wide range of monobrominated aromatic compounds can be obtained in excellent yields. The reaction can be operated using an extremely low catalyst loading (0.05 mol %) with the inexpensive brominating agent N-bromosuccinimide. The versatility of this catalytic protocol has been demonstrated by the scale-up reaction with a 0.01 mol % catalyst loading to provide the selectively halogenated compound in quantitative yield.
METHOD FOR PRODUCING 1,5-ANHYDRO-1-SUBSTITUTED PHENYL-D-GLUCITOL COMPOUNDS
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Paragraph 0065, (2017/07/25)
PROBLEM TO BE SOLVED: To provide a novel method for producing 1,5-anhydro-1-substituted phenyl-D-glucitol compounds useful as medicines having the action of inhibiting sodium-dependent glucose cotransporters 1. SOLUTION: The present invention provides a method for producing 1,5-anhydro-1-substituted phenyl-D-glucitol compounds represented by formula (XI), wherein, compounds represented by formula (II) are converted through a plurality of steps to produce the compounds represented by formula (XI). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT
METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS
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Paragraph 176; 178, (2016/01/25)
Provided herein include methods and compositions for treating diseases or conditions. In some embodiments provided are methods for treating one or more diseases or conditions selected from the group consisting of hypertension, heart failure, dyspnea, and
Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases
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Paragraph 0146; 0147, (2015/03/04)
Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formu
SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF
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Page/Page column 50, (2010/04/23)
The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.
Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases
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Page/Page column 78, (2010/11/26)
Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Diaminopyrimidines as P2X3 and P2X2/3 antagonists
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Page/Page column 80, (2010/02/14)
Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
Compounds having activity as inhibitors of cytochrome P450RAI
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Page column 124, (2010/01/31)
Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
Compounds having activity as inhibitors of cytochrome P450RAI
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Page column 121, (2010/01/31)
Compounds having Formula 2 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.
Compounds having activity as inhibitors of cytochrome P450RAI
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Page column 45, 122-123, (2010/11/29)
Compounds having Formula 8 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids.