34933-06-7

Basic information

• Product Name: 3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
• Synonyms: 3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one;ACETIC ACID (2R,3S)-5-(2-DIMETHYLAMINO-ETHYL)-2-(4-METHOXY-PHENYL)-4-OXO-2,3,4,5-TETRAHYDRO-BENZO[B][1,4]THIAZEPIN-3-YL ESTER;1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-;(2S,3R)-2,3-Dihydro-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-1,5-benzothiazepine-4(5H)-one acetate;Acetic acid [(2S)-2,3,4,5-tetrahydro-5-[2-(dimethylamino)ethyl]-4-oxo-2β-(4-methoxyphenyl)-1,5-benzothiazepin]-3α-yl ester;l-trans-Diltiazem;5-[2-(Dimethylamino)ethyl]-2,3,4,5-tetrahydro-2-(4-methoxyphenyl)-4-oxo-1,5-benzothiazepin-3-ol acetate;(2R,3S)-2,3-Dihydro-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-1,5-benzothiazepine-4(5H)-one acetate
• CAS NO: 34933-06-7
• Molecular Formula: C₂₂H₂₆N₂O₄S
• Molecular Weight: 414.51784
• EINECS: 252-295-2
• Product Categories: Miscellaneous Biochemicals
• Mol File: 34933-06-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 594.4°Cat760mmHg
• Flash Point: 313.3°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 4.27E-14mmHg at 25°C
• Refractive Index: 1.62
• CAS DataBase Reference: 3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(34933-06-7)
• EPA Substance Registry System: 3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(34933-06-7)

Safety Data

• Hazardous Substances Data: 34933-06-7(Hazardous Substances Data)

Usage

Definition

ChEBI: A lactam that is 2,3-dihydro-1,5-benzothiazepin-4(5H)-one in which positions 2 and 3 are substituted by 4-methoxyphenyl and acetoxy, respectively, while the hydrogen attached to the nitrogen is substituted by a 2-(dimethylamino)ethyl gro p.

InChI:InChI=1/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3

Upstream product

• 80344-17-8 3-[2-(2-dimethylamino-ethylamino)-phenylsulfanyl]-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid 
• 108-24-7 acetic anhydride 
• 23515-44-8 5-(2-dimethylamino-ethyl)-3t-hydroxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 27068-88-8 3c-hydroxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 23515-44-8 5-(2-dimethylamino-ethyl)-3c-hydroxy-2r-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one 
• 27068-88-8 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 
• 154076-93-4 ethyl (Z)-2-(2-methoxyethoxy)methoxy-3-(4-methoxyphenyl)-2-propenoate 

Downstream Products

• 31964-28-0 {2-[3c-acetoxy-2r-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazepin-5-yl]-ethyl}-trimethyl-ammonium; iodide 
• 31964-30-4 {2-[3c-acetoxy-2r-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazepin-5-yl]-ethyl}-dimethyl-propyl-ammonium; bromide 
• 31964-29-1 {2-[3c-acetoxy-2r-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazepin-5-yl]-ethyl}-ethyl-dimethyl-ammonium; bromide 
• 75472-92-3 L-cis-diltiazem 
• 42399-41-7 diltiazem 

Relevant articles and documents

Process for the preparation of Diltiazem

A process for the preparation of Diltiazem of formula (I) STR1 starting from the corresponding benzothiazepine and carried out throughout a 11 the steps in a single solvent.

Stereoselective addition of 2-aminothiophenol to α-alkoxycinnamic acid derivatives - Alternative synthesis of (±)-diltiazem

A stereocontrolled synthesis of (±)-diltiazem by applying nucleophilic addition of 2-aminothiophenol to α-alkoxycinnamic acid derivatives is described.