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350-30-1

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350-30-1 Usage

Synthesis

In certain instances, when both chloro and nitro may act as a leaving group, a surprising selectivity of one over the other is observed, for example chloro-2,5- dinitrobenzene was converted to 4-fluoro-3-chloronitrobenzene.

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 350-30-1 differently. You can refer to the following data:
1. 2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.
2. 2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:benzoimidolones on Ameba resinmethyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557oSynthetic Communications, 21, p. 505, 1991 DOI: 10.1080/00397919108016776

General Description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)6 and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

Check Digit Verification of cas no

The CAS Registry Mumber 350-30-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,5 and 0 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 350-30:
(5*3)+(4*5)+(3*0)+(2*3)+(1*0)=41
41 % 10 = 1
So 350-30-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H3ClFNO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H

350-30-1 Well-known Company Product Price

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  • Alfa Aesar

  • (A16183)  2-Chloro-1-fluoro-4-nitrobenzene, 98%   

  • 350-30-1

  • 25g

  • 549.0CNY

  • Detail
  • Alfa Aesar

  • (A16183)  2-Chloro-1-fluoro-4-nitrobenzene, 98%   

  • 350-30-1

  • 50g

  • 873.0CNY

  • Detail
  • Alfa Aesar

  • (A16183)  2-Chloro-1-fluoro-4-nitrobenzene, 98%   

  • 350-30-1

  • 100g

  • 1655.0CNY

  • Detail
  • Alfa Aesar

  • (A16183)  2-Chloro-1-fluoro-4-nitrobenzene, 98%   

  • 350-30-1

  • 500g

  • 8010.0CNY

  • Detail
  • Aldrich

  • (233234)  3-Chloro-4-fluoronitrobenzene  98%

  • 350-30-1

  • 233234-25G

  • 951.21CNY

  • Detail

350-30-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Chloro-4-fluoronitrobenzene

1.2 Other means of identification

Product number -
Other names 3-chloro-4-fluoro-1-nitrobenzene

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:350-30-1 SDS

350-30-1Relevant articles and documents

Catalyst and application thereof in synthesis of aromatic fluorine compounds

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Paragraph 0042-0044, (2020/11/10)

The invention belongs to the field of catalyst preparation and application, and particularly relates to a catalyst and application thereof in synthesis of aromatic fluorine compounds. The nickel catalyst is dichloro-bis-(tri-cyclohexylphosphine) nickel, and the molecular formula of the nickel catalyst is Ni (Py3) 2Cl2. The nickel catalyst is applied to catalyzing inorganic fluoride to replace aromatic chloride to synthesize fluoride. The catalyst has the advantages of easily available reagents, simple catalyst synthesis, simple operation conditions, low reaction temperature, high reaction yield and less time consumption.

O-dichlorobenzene with a quinolone drugs for coproduction method of key intermediate

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Paragraph 0020; 0066-0067, (2017/01/19)

The invention relates to the field of methods for preparing medicinal intermediates, in particular to the field of methods for preparing key intermediates of quinolone medicines, and develops a method for coproducing the key intermediates of the quinolone medicines by using o-dichlorobenzene as a raw material. The method comprises the following steps of: nitrifying the o-dichlorobenzene serving as the raw material, and performing distillation, purification and stepwise crystallization to obtain 2,3-dichloronitrobenzene and 3,4-dichloronitrobenzene; performing fluoridation on the 2,3-dichloronitrobenzene to obtain 3-chloro-2-fluoronitrobenzene, performing chlorination to obtain 2,6-dichlorofluorobenzene, performing nitration to obtain 1,3-dichloro-2-fluoro-4-nitrobenzene, and finally performing fluoridation to obtain 2,3,4-trifluoronitrobenzene; and performing fluoridation on the 2,3,4-trifluoronitrobenzene to obtain 3-chloro-4-fluoronitrobenzene, performing chlorination to obtain 1,3-dichloro-4-fluorobenzene, and finally performing acylation reaction on the 1,3-dichloro-4-fluorobenzene and acetylchloride to obtain 2,4-dichloro-5-fluoroacetophenone.

A PROCESS FOR SYNTHESIS OF 2, 4-DICHLORO-5- FLUOROACETOPHENONE (DCFA)

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Page/Page column 15, (2010/07/10)

A process for synthesis of 2,4-dichloro-5-fluoro acetophenone (DCFA) is disclosed. The process comprises first reacting 3,4-dichloronitrobenzene with potassium fluoride having bulk density in the range of 0.2 to 1.3, to form a fluorinated intermediate product, then reacting the intermediate product with chlorine to form dichlorofluorobenzene and finally acylating dichlorofluorobenzene using an acylating agent to form a mixture containing DCFA along with impurities, followed by purification and enrichment of DCFA in the mixture by melt crystallization.

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