35011-47-3

Basic information

• Product Name: 2,4,5-Triamino-6-hydroxypyrimidine sulfate
• Synonyms: 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE SULFATE HYDRATE;2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE HYDRATE;2,5,6-TRIAMINO-4(1H)-PYRIMIDINONE SULFATE HYDRATE;2,5,6-Triamino-4(1H)-pyrimidinone sulfate;4-hydroxy-2,5,6-triaminopyrimidine sulf. monohydr. (6-2,4,5);4-HYDROXY-2,5,6-TRIAMINOPYRIMIDINE;2,5,6-triamino-4-pyrimidol sulfate salt;4-hydroxy-2,5,6-triaminopyrimidine sulfate salt
• CAS NO: 35011-47-3
• Molecular Formula: C₄H₇N₅O*H₂O₄S
• Molecular Weight: 239.21
• EINECS: 216-500-9
• Product Categories: Heterocyclic Compounds
• Mol File: 35011-47-3.mol

Chemical Properties

• Melting Point: ≥300 °C(lit.)
• Boiling Point: 277 °C at 760 mmHg
• Flash Point: 121.3 °C
• Appearance: yellow-beige crystalline powder
• Density: 2.033g/cm3
• Refractive Index: 1.772
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Soluble in DMSO.
• CAS DataBase Reference: 2,4,5-Triamino-6-hydroxypyrimidine sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-Triamino-6-hydroxypyrimidine sulfate(35011-47-3)
• EPA Substance Registry System: 2,4,5-Triamino-6-hydroxypyrimidine sulfate(35011-47-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: UW7175000
• Hazardous Substances Data: 35011-47-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4,5-Triamino-6-hydroxypyrimidine sulfate is used as a building block for the preparation of guanines and other purine derivatives with antiviral activities. These compounds are essential in the development of new antiviral drugs, as they can potentially inhibit viral replication and reduce the severity of viral infections.
Used in Chemical Synthesis:
2,4,5-Triamino-6-hydroxypyrimidine sulfate is used as an intermediate in the preparation of labelled 2-Amino-6,8-dihydroxypurine Hydrochloride (A604920), a substituted 5-aminopyrimidine with antioxidative activity. This labelled compound can be utilized in various research applications, such as studying the mechanisms of oxidative stress and developing novel antioxidants for therapeutic use.

用途

6-Hydroxy-2,4,5-triaminopyrimidine, Sulfate (cas# 35011-47-3) is a compound useful in organic synthesis.

Purification Methods

This salt has very low solubility in H2O. It is best purified by conversion into the dihydrochloride salt, which is then re-converted to the insoluble sulfate salt. The sulfate salt (2.57g, 10mmoles) is suspended in H2O (20mL) containing BaCl2 (10mmoles) and stirred in a boiling water bath for 15minutes. After cooling, the insoluble BaSO4 is filtered off and washed with boiling H2O (10mL). The combined filtrate and washings are made acidic with HCl and evaporated to dryness. The residual hydrochloride salt is recrystallised from H2O by adding conc HCl whereby the dihydrochloride salt separates as clusters which darken at 260o and dec > 300o[darkening > 360o]. [Baugh & Shaw J Org Chem 29 3610 1964, King & Spengley J Chem Soc 2144 1952]. The hydrochloride is then dissolved in H2O, and while hot an equivalent of H2SO4 is added when the sulfate separates as a white microcrystalline solid which is filtered off washed liberally with H2O and dried in vacuum over P2O5. [Albert & Wood J Appl Chem London 3 521 1953, UV: Cavalieri et al. J Am Chem Soc 70 3875 1948; see also Pfleiderer Chem Ber 90 2272 1957, Traube Chem Ber 33 1371 1900.] The hydrochloride has m > 300o. [Beilstein 25 II 384, 25 III/IV 3648.]

InChI:InChI=1/C4H7N5O4S/c5-1-2(6)8-4(7)9-3(1)13-14(10,11)12/h5H2,(H,10,11,12)(H4,6,7,8,9)

Upstream product

• 2387-48-6 2,4-diamino6-hydroxy-5-nitroso pyrimidine 

Downstream Products

• 49647-45-2 2-amino-6,8-bis-(4-butyl-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one 
• 49647-41-8 2-amino-6,8-bis-(4-chloro-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one 
• 49647-43-0 2-amino-6,8-bis-(3,4-dimethyl-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one 
• 49647-42-9 2-amino-6,8-bis-(3,4-dichloro-phenyl)-7,7-dioxo-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one 
• 49647-44-1 2-amino-7,7-dioxo-6,8-bis-(3-trifluoromethyl-phenyl)-3,6,7,8-tetrahydro-7λ⁶-thieno[3,4-g]pteridin-4-one 
• 611-55-2 6,7-Dimethylpterin 
• 88713-39-7 <(benzoyloxy-2 ethoxymethyl)-1 carboxamido>-5 diamino-2,4 hydroxy-6 pyrimidine 
• 13040-58-9 7-methylpterin 
• 70-55-3 toluene-4-sulfonamide 
• 289-95-2 PYRIMIDINE 
• 2432-20-4 2-methyl-pteridine 
• 916044-84-3 2'-O-acetyl-N₂-(N,N-dimethylaminomethylene)-1'-O-(4-methoxybenzyl)-3-[2-(4-nitrophenyl)ethyl]biopterin 
• 916044-85-4 C₃₀H₃₃N₇O₇ 
• 1015691-42-5 C₂₂H₂₆N₆O₅ 

Relevant articles and documents

Preparation method of 2,4,5-triamino-6-hydroxypyrimidine sulfate and folic acid

The invention relates to a preparation method of 2,4,5-triamino-6-hydroxypyrimidine sulfate and folic acid. The preparation method comprises the following steps: enabling cyanoacetate and sodium nitrite to be subjected to reaction under the action of an organic solvent and/or an inorganic solvent and an acidic substance to obtain 2-oximidocyanoacetate; then, enabling the 2-oximidocyanoacetate andguanidine hydrochloride to be subjected to reaction under an alkaline condition to obtain 2,4-diamino-5-isonitroso-6-oxopyrimidine; enabling the 2,4-diamino-5-isonitroso-6-oxopyrimidine and hydrogen gas to be subjected to reaction under an alkaline condition by means of action of Pd/C to obtain 2,4,5-triamino-6-hydroxypyrimidine, and adding sulfuric acid to adjust the pH value to obtain 2,4,5-triamino-6-hydroxypyrimidine sulfate; and then, adding trichloroacetone and N-(4-aminobenzoyl)-L-glutamic acid to be subjected to reaction in a buffer solution under the action of a catalyst molecular sieve so as to obtain the folic acid. Based on the process route, the invention explores the influences of different reaction steps and refining conditions on the preparation route of 2,4,5-triamino-6-hydroxypyrimidine sulfate and the folic acid so as to reduce the wastewater pollution while increasing the yield.

IKK-β as target to 2-acetyl-8-substituted guanine derivatives, application and its preparation method (by machine translation)

The present invention discloses a target IKK-β to 2-acetyl-8-substituted guanine derivatives, application and its preparation method, the compounds of the present invention to the A549 cell inhibitory activity, the increase of the density of the as to, its rate will also increase, however, the kind of compound, to b16-f10, H460 and U251 cell strain basic noec role, this kind of selectivity for inhibition of specific anti-tumor medicament as the same is of special significance. (by machine translation)