35031-43-7

Basic information

• Product Name: 2-benzyloxyimino-3-phenylpropionic acid
• Synonyms: 2-benzyloxyimino-3-phenylpropionic acid
• CAS NO: 35031-43-7
• Molecular Weight: 269.3
• Mol File: 35031-43-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-benzyloxyimino-3-phenylpropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyloxyimino-3-phenylpropionic acid(35031-43-7)
• EPA Substance Registry System: 2-benzyloxyimino-3-phenylpropionic acid(35031-43-7)

Safety Data

• Hazardous Substances Data: 35031-43-7(Hazardous Substances Data)

Upstream product

• 99033-95-1 2-hydroxyimino-3-phenylpropanoic acid 
• 100-44-7 benzyl chloride 
• 50877-94-6 methyl 2-(N-hydroxyimino)-3-phenylpropanoate 
• 114858-59-2 2-[(E)-Benzyloxyimino]-3-phenyl-propionic acid methyl ester 
• 607-81-8 diethyl 2-benzylmalonate 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 6943-96-0 ethyl 2-(hydroxyimino)-3-phenylpropanoate 
• 70771-87-8 ethyl 2-benzyloxyimino-3-phenylpropionate 
• 156-06-9 2-oxo-3-(phenyl)propionic acid 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 49769-78-0 2-benzyl-malonic acid dimethyl ester 
• 100-39-0 benzyl bromide 

Downstream Products

• 1345343-90-9 N-(α-benzyloxime-3-phenylpropionyl)proline 
• 1345344-06-0 (E)-cyclo[N-benzyloxy-2-(phenylmethylene)glycylprolyl] 
• 408539-45-7 2-benzyloxyimino-3-phenyl-propionyl chloride 

Relevant articles and documents

Synthesis and activity evaluation of the cyclic dipeptides arylidene N-alkoxydiketopiperazines

A series of arylidene N-alkoxydiketopiperazines was designed and stereoselectively synthesized via oxime-ether formation and intramolecular acylation. Possible cyclization and acid-catalyzed rearrangement-fragmentation mechanisms were discussed. The crystal structure of the novel diketopiperazine further confirmed the rearrangement mechanism. Most compounds exhibited antitumor activity. Several compounds were more potent against caspase-3. Specifically, compounds 6e, 6g, and 6f inhibited caspase-3 at IC50values lying within the low micromolar range and demonstrated good selectivity. The binding modes of alkoxydiketopiperazines in the active center of caspase-3 were also discussed based on the molecular docking results.

Stereoselective synthesis and rearrangement-fragmentation of arylidene N-alkoxydiketopiperazines

A stereoselective synthesis of arylidene N-alkoxydiketopiperazines via oxime-ether formation and intramolecular acylation is described, followed by an acid-catalysed rearrangement-fragmentation to give novel diketopiperazine hemiaminal derivatives with us