351418-50-3

Basic information

• Product Name: Benzaldehyde, 2-bromo-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS NO: 351418-50-3
• Molecular Formula: C13H19BrO2Si
• Molecular Weight: 315.282
• Mol File: 351418-50-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2-bromo-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2-bromo-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(351418-50-3)
• EPA Substance Registry System: Benzaldehyde, 2-bromo-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-(351418-50-3)

Safety Data

• Hazardous Substances Data: 351418-50-3(Hazardous Substances Data)

Upstream product

• 288-32-4 1H-imidazole 
• 2973-80-0 2-bromo-5-hydroxybenzaldehyde 
• 12125-02-9 ammonium chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 906673-24-3 AN₂₇₂₈ 
• 1187190-70-0 1,3-dihydro-1,5-dihydroxy-2,1-benzoxaborolane 
• 906673-51-6 1-bromo-4-tert-butyldimethylsiloxy-2-methoxymethoxymethylbenzene 
• 906673-48-1 2-bromo-5-tert-butyldimethylsiloxybenzylalcohol 
• 1393367-77-5 (Z)-(4-bromo-3-(2-bromovinyl)phenoxy)(tert-butyl)dimethylsilane 
• 1393367-76-4 (E)-(4-bromo-3-(2-bromovinyl)phenoxy)(tert-butyl)dimethylsilane 

Relevant articles and documents

Preparation method of crisaborole

The invention discloses a preparation method of crisaborole, which comprises the following steps: S1, reacting 2-bromo-5-hydroxybenzaldehyde with a hydroxyl protecting reagent in a solvent in the presence of alkali to obtain a compound I; S2, reducing the compound I in a solvent in the presence of a reducing agent to obtain a compound I I; S3, reacting the compound I with a hydroxyl protection reagent in a solvent in the presence of alkali to obtain a compound IV; S4, reacting the compound IV with boric acid ester in a solvent in the presence of alkali to obtain a compound V; S5, removing a hydroxyl protecting group from the compound V to obtain a compound VI; and S6, reacting the compound IV with p-fluorobenzonitrile to obtain crisaborole. A hydroxyl protecting group which is more beneficial to removal is adopted in the route, synthesis of boric acid ester is facilitated, side reactions are reduced, the yield is obviously increased, and the method is easy to operate, low in cost and beneficial to industrial production.

Synthesis of Monodisperse Naphthalene Dendrons for the Application of Dendrimers

Syntheses of dendrons for dendrimer applications are described using napthyl and urethane derivatives. The napthol, 1-(3-hydroxy-6-(methoxymethoxy)naphthalen-1-yl)ethan-1-one (h), was synthesized by employing Au-catalyzed cyclization of the corresponding

1H-phosphindoles as structural units in the synthesis of chiral helicenes

Building helicenes: A photochemical cyclization approach affords helicenes in which the fused ring sequence ends with a phosphole unit (see scheme). The stereogenic phosphorus centers of the substrates control the screw sense of helical chirality. The terminal phosphole units undergo photochemical [2+2] annulations to give dimeric helical structures. Copyright