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5-CHLORO-3-IODO-1H-INDAZOLE is a chemical compound with the molecular formula C7H4ClIN, belonging to the class of indazole compounds. It is characterized by a five-membered ring structure and is notable for its chlorine and iodine substituents. This unique structure and properties make it a valuable building block for the synthesis of novel compounds with potential biological activities.

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  • 351456-45-6 Structure
  • Basic information

    1. Product Name: 5-CHLORO-3-IODO-1H-INDAZOLE
    2. Synonyms: 5-CHLORO-3-IODO-1H-INDAZOLE;5-CHLORO-3-IODOINDAZOLE;1H-Indazole, 5-chloro-3-iodo-;351456-46-5
    3. CAS NO:351456-45-6
    4. Molecular Formula: C7H4ClIN2
    5. Molecular Weight: 278.48
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 351456-45-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 391.471 °C at 760 mmHg
    3. Flash Point: 190.555 °C
    4. Appearance: /
    5. Density: 2.157 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.785
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: N/A
    10. CAS DataBase Reference: 5-CHLORO-3-IODO-1H-INDAZOLE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-CHLORO-3-IODO-1H-INDAZOLE(351456-45-6)
    12. EPA Substance Registry System: 5-CHLORO-3-IODO-1H-INDAZOLE(351456-45-6)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 351456-45-6(Hazardous Substances Data)

351456-45-6 Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-3-IODO-1H-INDAZOLE is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure and properties allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-CHLORO-3-IODO-1H-INDAZOLE is used as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its unique structure can contribute to the development of more effective and environmentally friendly products.
Used in Materials Science:
5-CHLORO-3-IODO-1H-INDAZOLE is used in materials science for the development of new materials with specific properties. Its unique structure can be utilized to create materials with improved performance in various applications, such as electronics, coatings, and adhesives.
Used in Organic Synthesis:
As a chemical compound with chlorine and iodine substituents, 5-CHLORO-3-IODO-1H-INDAZOLE is used in various organic synthesis processes. Its reactivity and unique structure make it a valuable component in the synthesis of novel compounds with potential applications in different industries.
Used in Research and Development:
5-CHLORO-3-IODO-1H-INDAZOLE is used in research and development for the exploration of its potential applications and properties. Its unique structure and properties make it an interesting subject for scientific studies, which can lead to the discovery of new applications and uses in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 351456-45-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,1,4,5 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 351456-45:
(8*3)+(7*5)+(6*1)+(5*4)+(4*5)+(3*6)+(2*4)+(1*5)=136
136 % 10 = 6
So 351456-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H4ClIN2/c8-4-1-2-6-5(3-4)7(9)11-10-6/h1-3H,(H,10,11)

351456-45-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-chloro-3-iodo-2H-indazole

1.2 Other means of identification

Product number -
Other names 1H-Indazole,5-chloro-3-iodo

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:351456-45-6 SDS

351456-45-6Downstream Products

351456-45-6Relevant articles and documents

SMAC MIMETICS USED AS IAP INHIBITORS AND USE THEREOF

-

Sheet 0104; 0105, (2020/12/10)

Disclosed are a class of SMAC mimetics used as IAP inhibitors, and in particular disclosed are compounds as shown in formula (I), isomers thereof, and pharmaceutically acceptable salts thereof. The IAP inhibitors are drugs for treating cancers, in particu

Suzuki-type cross-coupling reaction of unprotected 3-iodoindazoles with pinacol vinyl boronate: An expeditive C-3 vinylation of indazoles under microwave irradiation

Vera, Gonzalo,Diethelm, Benjamín,Terraza, Claudio A.,Recabarren-Gajardo, Gonzalo

, (2018/09/26)

Herein we report an expeditive C-3 vinylation of unprotected 3-iodoindazoles under microwave irradiation. Ten C-5 substituted 3-vinylindazole derivatives, nine of them novel, were synthesized through this method, which proceeds in moderate to excellent yields starting from C-5 substituted 3-iodoindazole derivatives. In all cases, the C-3 vinylated derivative was the only isolated product. This methodology allows access to 3-vinylated indazoles selectively and directly without the need of N-protection. 3-Vinylindazoles could be interesting synthetic intermediates allowing access to biologically active molecules.

THERAPEUTIC INHIBITORY COMPOUNDS

-

Paragraph 00178, (2019/01/08)

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds which are complement factor D inhibitors. Such compounds are useful for treating complement related disorders including, but are not limited to, autoimmune, inflammatory, and neurodegenerative diseases.

THERAPEUTIC INHIBITORY COMPOUNDS

-

Paragraph 00208, (2017/07/04)

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds which are complement factor D inhibitors. Such compounds are useful for treating complement related disorders including, but are not limited to, autoimmune, inflammatory, and neurodegenerative diseases.

New CRTh2 antagonists.

-

Paragraph 0198, (2013/03/26)

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

NEW CRTh2 ANTAGONISTS

-

Page/Page column 73-74, (2013/03/26)

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome

Lynch, Stephen M.,Devicente, Javier,Hermann, Johannes C.,Jaime-Figueroa, Saul,Jin, Sue,Kuglstatter, Andreas,Li, Hongju,Lovey, Allen,Menke, John,Niu, Linghao,Patel, Vaishali,Roy, Douglas,Soth, Michael,Steiner, Sandra,Tivitmahaisoon, Parcharee,Vu, Minh Diem,Yee, Calvin

, p. 2793 - 2800 (2013/07/05)

Using a structure based design approach we have identified a series of indazole substituted pyrrolopyrazines, which are potent inhibitors of JAK3. Intramolecular electronic repulsion was used as a strategy to induce a strong conformational bias within the ligand. Compounds bearing this conformation participated in a favorable hydrophobic interaction with a cysteine residue in the JAK3 binding pocket, which imparted high selectivity versus the kinome and improved selectivity within the JAK family.

Indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation

-

, (2008/06/13)

Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

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