35161-65-0

Basic information

• Product Name: N,N'-DIFORMYL-1,6-DIAMINOHEXANE
• Synonyms: N,N'-DIFORMYL-1,6-DIAMINOHEXANE
• CAS NO: 35161-65-0
• Molecular Formula: C₈H₁₆N₂O₂
• Molecular Weight: 172.22
• Mol File: 35161-65-0.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 445.8 °C at 760 mmHg
• Flash Point: 203 °C
• Appearance: /
• Density: 0.996 g/cm³
• CAS DataBase Reference: N,N'-DIFORMYL-1,6-DIAMINOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-DIFORMYL-1,6-DIAMINOHEXANE(35161-65-0)
• EPA Substance Registry System: N,N'-DIFORMYL-1,6-DIAMINOHEXANE(35161-65-0)

Safety Data

• Hazardous Substances Data: 35161-65-0(Hazardous Substances Data)

Usage

General Description

N,N'-Diformyl-1,6-diaminohexane is a chemical compound with the molecular formula C10H20N2O2. It is a diamine derivative with two formyl groups attached to the terminal amino groups of a hexamethylenediamine chain. N,N'-DIFORMYL-1,6-DIAMINOHEXANE is commonly used as a crosslinking agent in the production of thermosetting resins and polyamides, which are used in the manufacturing of coatings, adhesives, and plastics. N,N'-Diformyl-1,6-diaminohexane is also utilized in the production of chelating agents and as a building block in organic synthesis. It is important to handle this chemical with care and in accordance with safety guidelines, as it can be harmful if ingested, inhaled, or in contact with skin or eyes.

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 107-31-3 Methyl formate 
• 111-69-3 hexanedinitrile 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 69545-57-9 C₁₄H₂₀N₆O₂ 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 
• 67-56-1 methanol 
• 822-06-0 Hexamethylene diisocyanate 
• 77287-34-4 formamide 
• 64-18-6 formic acid 

Downstream Products

• 13093-04-4 N,N'-dimethyl-1,6-hexanediamine 
• 1333956-70-9 C₃₀H₄₆N₄O₂ 
• 1333956-79-8 C₃₈H₄₆N₄O₄ 
• 1333956-90-3 C₂₄H₃₄N₄O₄ 
• 929-57-7 1,6-di-isocyanohexane 

Relevant articles and documents

Carbachol dimers as homobivalent modulators of muscarinic receptors

A series of homodimers of the well-known cholinergic agonist carbachol have been synthesized, showing the two agonist units symmetrically connected through a methylene chain of variable length. The new compounds have been tested on the five cloned muscarinic receptors (hM1-5) expressed in CHO cells by means of equilibrium binding studies, showing an increase in affinity by rising the number of methylene units up to 7 and 9. Functional experiments on guinea-pig ileum and assessment of ERK1/2 phosphorylation on hM1, hM2 and hM3 on CHO cells have shown that the new compounds are endowed with muscarinic antagonistic properties. Kinetic binding studies have revealed that some of the tested compounds are able to slow the rate of dissociation of NMS, suggesting a bitopic behavior. Docking simulations, performed on the hM1 and hM2 receptors, give a sound rationalization of the experimental data revealing how these compounds are able to interact with both orthosteric and allosteric binding sites depending on the length of their connecting chain.

Catalytic N-diphosphonomethylation of amino alkanols and bisamino alkanes using tris(trimethylsilyl) phosphite as a convenient synthon

The new mono- and bis(aminomethylenediphosphonic) acids are synthesized for the first time via unique reaction of tris(trimethylsilyl) phosphite and various N-formyl amino alkanols or bis(N-formyl amino) alkanes at the presence of effective catalyst – trimethylsilyl triflate under mild conditions. The further treatment of initially formed trimethylsilyl intermediates with the methanol excess resulted in the crystalline mono- and bis(aminomethylenediphosphonic) acids in high yields. The catalytic scheme of target substances formation is proposed and discussed in detail. The structures of target acids were confirmed by the 1H, 13C, 31P NMR spectra and high resolution mass spectra (HRMS). The resulting compounds are of great interest as perspective bioactive substances with versatile properties and effective polydentate ligands.

A Combined Photochemical and Multicomponent Reaction Approach to Precision Oligomers

We introduce the convergent synthesis of linear monodisperse sequence-defined oligomers through a unique approach, combining the Passerini three-component reaction (P-3CR) and a Diels–Alder (DA) reaction based on photocaged dienes. A set of oligomers is prepared resting on a Passerini linker unit carrying an isocyano group for chain extension by P-3CR and a maleimide moiety for photoenol conjugation enabling a modular approach for chain growth. Monodisperse oligomers are accessible in a stepwise fashion by switching between both reaction types. Employing sebacic acid as a core unit allows the synthesis of a library of symmetric sequence-defined oligomers. The oligomers consist of alternating P-3CR and photoblocks with molecular weights up to 3532.16 g mol?1, demonstrating the successful switching from P-3CR to photoenol conjugation. In-depth characterization was carried out including size-exclusion chromatography (SEC), high-resolution electrospray ionization mass spectrometry (ESI-MS) and NMR spectroscopy, evidencing the monodisperse nature of the precision oligomers.

Ru/ceria-catalyzed direct formylation of amines and CO to produce formamides

We herein report a new strategy of directly converting amines and CO to formamides with 100% atom utilization efficiency. It is suitable for up to 25 amine substrates with no additives. Ru/ceria is found to be an excellent catalyst for this reaction due the efficient co-activation of CO and amine on Ru species.