352-91-0Relevant articles and documents
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Cherbuliez,E. et al.
, p. 1132 - 1135 (1960)
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Triazolopyrimidines
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, (2008/06/13)
Novel triazolopyrimidines of the formula in which R1, R2, R3 and X have the meanings given in the description, a process for preparing these novel substances and their use for controlling undesirable microorganisms and animal pests. Novel amines of the formula in which R4 has the meanings given in the description, and processes for their preparation.
A Rapid and Efficient Method for the Fluoroalkylation of Amines and Amides. Development of a Method Suitable for Incorporation of the Short-Lived Positron Emitting Radionuclide Fluorine-18
Chi, Dae Yoon,Kilbourn, Michael R.,Katzenellenbogen, John A.,Welch, Michael J.
, p. 658 - 664 (2007/10/02)
We have described a two-step method for the preparation of fluoroalkyl-substituted amines and amides.The sequence involves fluoride ion displacement of a haloalkyl trifluoromethanesulfonate (triflate), followed by fluoroalkylation of the heteroatom system (amine or amide) by the fluoroalkyl halide.Alternatively, the fluoroalkyl halide can be prepared by halofluorination of a terminal olefin.These reactions have been used to prepare various fluoroalkyl derivatives of N-phenylpiperazine and N-fluoroalkyl derivatives of the neuroleptic agent spiperone (7).The sequence is rapid, convenient, and efficient, even when fluoride ion is the limiting reagent.Therefore, it is readily adaptable to the preparation of a variety of compounds labeled with the short half-life (t1/2 = 110 min) positron-emitting radionuclide fluorine-18.