356783-31-8

Basic information

• Product Name: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-
• Synonyms: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-;6-fluoro-3-oxo-3,4-dihydropyrazine-2-carbonitrile;6-Fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile;6-fluoro-3-hydroxypyrazine-2-carbonitrile
• CAS NO: 356783-31-8
• Molecular Formula: C₅H₂FN₃O
• Molecular Weight: 139.0872832
• Mol File: 356783-31-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• PKA: 7.74±0.60(Predicted)
• CAS DataBase Reference: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-(356783-31-8)
• EPA Substance Registry System: 2-Pyrazinecarbonitrile, 6-fluoro-3,4-dihydro-3-oxo-(356783-31-8)

Safety Data

• Hazardous Substances Data: 356783-31-8(Hazardous Substances Data)

Usage

Appearance

6-fluoro-3,4-dihydro-3-oxo-2-Pyrazinecarbonitrile is a pale yellow to light yellow solid.

Melting Point

126 - 129℃

Uses

6-Fluoro-3-hydroxypyrazine-2-carbonitrile is used in the synthesis of intermediate of Favipiravir (F103350).

Upstream product

• 356783-56-7 6-fluoro-3-(4-hydroxyphenoxy)-2-pyrazinecarbonitrile 
• 356783-52-3 6-fluoro-3-(4-methoxyphenoxy)-2-pyrazinecarbonitrile 
• 98-96-4 pyrazinamide 
• 18960-19-5 1,4-dioxopyrazinamide 
• 356783-16-9 3,6-dichloropyrazine-2-carbonitrile 
• 1023813-21-9 3,6-dichloropyrazine-2-carboxamide 
• 98142-97-3 3,6-dioxopiperazine-2-carboxamide 
• 41394-71-2 2-(chloroacetylamino)propanedioic acid diethyl ester 
• 1374986-06-7 C₇H₄FN₃O₃ 
• 1374986-05-6 methyl-5-chloroisoxazolo[4,5-b]pyrazine-3-carboxylate 
• 1374986-04-5 C₇H₅N₃O₄ 
• 1374986-03-4 C₁₁H₁₇N₃O₆ 
• 1374986-37-4 C₈H₉N₃O₅ 
• 1374986-35-2 C₈H₁₀N₂O₄ 

Downstream Products

• 259793-96-9 favipiravir 

Relevant articles and documents

Refining method of favipiravir

The invention provides a refining method of favipiravir. The method specifically comprises the following steps: 6-fluoro-3-hydroxy-2-cyanopyrazine reacts with hydrogen peroxide under an alkaline condition to obtain 6-fluoro-3-hydroxy-2-pyrazinamide; the 6-fluoro-3-hydroxy-2-pyrazinamide is prepared into an organic alkali salt in an anhydrous organic solvent, and then the pH value in water is adjusted to prepare high-purity 6-fluoro-3-hydroxy-2-pyrazinamide; and 6-fluoro-3-hydroxy-2-pyrazinamide and organic alkali are salified in an organic solvent, the salt has excellent crystallinity, high-purity favipiravir can be prepared with high yield through simple operation, the yield can reach 90% or above, and the HPLC purity reaches 99.9% or above.

PROCESS FOR PREPARATION OF FAVIPIRAVIR

The present invention relates to a process for the preparation of favipiravir and salts thereof. The present invention also relates to salts of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile with inorganic base, process for their preparation and conversion thereof to favipiravir. The present invention also relates to salts of 6-bromo-3-hydroxypyrazine-2-carboxamide with organic and inorganic base and their use in the preparation of favipiravir.

PROCESS FOR THE PREPARATION OF 3,6-DICHLOROCYANO PYRAZINE, 3,6-DIOXOPIPERAZINE DERIVATIVES AND PRODUCTION OF FAVIPIRAVIR THEREOF

The present invention relates to a method of preparing derivatives of 3,6-dichlorocyano pyrazine, 3,6-dioxopiperizin and the production of favipiravir by cyclization and chlorination mediated by ammonia or amine using POCl3 in the presence of pyridine or PCl5. [Formula] In derivatives of 3,6-dioxopiperazine (III), X represents CN, CONH2 or COOR2', R1, R 2 and R2' are individually selected from H, alkyl C1-C12, COOR3 and SO2R3, R 3 being a linear or branched lower alkyl substituted or unsubstituted.