357402-64-3Relevant articles and documents
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
Cheshire, David R.,?berg, Anders,Andersson, Gunilla M.K.,Andrews, Glen,Beaton, Haydn G.,Birkinshaw, Timothy N.,Boughton-Smith, Nigel,Connolly, Stephen,Cook, Tony R.,Cooper, Anne,Cooper, Sally L.,Cox, David,Dixon, John,Gensmantel, Nigel,Hamley, Peter J.,Harrison, Richard,Hartopp, Paul,K?ck, Helena,Leeson, Paul D.,Luker, Timothy,Mete, Antonio,Millichip, Ian,Nicholls, David J.,Pimm, Austen D.,St-Gallay, Steve A.,Wallace, Alan V.
, p. 2468 - 2471 (2011/06/17)
By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
Novel use of phenylheteroakylamine derivatives
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, (2008/06/13)
There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease.
