36051-31-7

Basic information

• Product Name: Guanosine 5'-triphosphate trisodium salt
• Synonyms: GUANOSINE-5'-TRIPHOSPHATE TETRASODIUM SALT;Guanosine 5′-triphosphate sodium salt hydrate;Guanosine 5'-(tetrahydrogen triphosphate), trisodium salt;GUANOSINE 5'-TRIPHOSPHATE SODIUM 100 MM SOLUTION MO;GUANOSINE 5'-TRIPHOSPHATE SODIUM*PREPARE D ENZYMATIC;GUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT HYDRATE 95+% HPLC;guanosine 5'-triphosphate sodium salt solution;Guanosine 5'-triphosphate trisodium salt
• CAS NO: 36051-31-7
• Molecular Formula: C₁₀H₁₃N₅O₁₄P₃*3Na
• Molecular Weight: 589.13
• EINECS: 252-847-2
• Mol File: 36051-31-7.mol
• Article Data: 1

Chemical Properties

• Appearance: white/powder
• Storage Temp.: −70°C
• Solubility: H2O: 50 mg/mL
• Stability: Hygroscopic
• BRN: 4113439
• CAS DataBase Reference: Guanosine 5'-triphosphate trisodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine 5'-triphosphate trisodium salt(36051-31-7)
• EPA Substance Registry System: Guanosine 5'-triphosphate trisodium salt(36051-31-7)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38-39/23/24/25
• Safety Statements: 26-36/37/39-45
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 36051-31-7(Hazardous Substances Data)

Usage

Uses

Guanosine 5′-triphosphate sodium salt solution has been used for reconstituting transducin during purification of transducin.

General Description

GTP is supplied as the disodium salt in crystal form.

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

Upstream product

• 127070-83-1 guanosine 5-monophosphate mono(trioctylammonium) salt 
• 85-32-5 Guanosine 5'-monophosphate 
• 69281-33-0 Guanosine 5'-monophosphate imidazolide 

Downstream Products

• 991-43-5 guanosine 5'-diphospho-D-mannose 

Relevant articles and documents

Convenient syntheses of cytidine 5'-triphosphate, guanosine 5'-triphosphate, and uridine 5'-triphosphate and their use in the preparation of UDP-glucose, UDP-glucuronic acid, and GDP-mannose

This paper compares enzymatic and chemical methods for the synthesis of cytidine 5'-triphosphate, guanosine 5'-triphosphate, and uridine 5'-triphosphate from the corresponding nucleoside monophosphates on scales of ~10 g. These nucleoside triphosphates are important as intermediates in Leloir pathway biosyntheses of complex carbohydrates; the nucleoside monophosphates are readily available commercially. The best route to CTP is based on phosphorylation of CMP using adenylate kinase (EC 2.7.4.3); the route to GTP involves phosphorylation of GMP using guanylate kinase (EC 2.7.4.8); chemical deamination of CTP (prepared enzymatically from CMP) is the best synthesis of UTP. For the 10-200-mmol-scale reactions described in this paper, it is more convenient to prepare phosphoenolpyruvate (PEP), used in the enzymatic preparations, from D-(-)-3-phosphoglyceric acid (3-PGA) in the reaction mixture rather than to synthesize PEP in a separate chemical step. The in situ conversion of 3-PGA to PEP requires the coupled action of phosphoglycerate mutase (EC 2.7.5.3) and enolase (EC 4.2.1.11). The enzyme-catalyzed syntheses of uridine 5'-diphosphoglucose (UDP-Glc), uridine 5'-diphosphoglucuronic acid (UDP-GlcUA), and guanosine 5'-diphosphomannose (GDP-Man) illustrate the use of the nucleoside triphosphates.