36051-68-0

Basic information

• Product Name: Cytidine 5'-triphosphate disodium salt
• Synonyms: cytidine5’-(disodiumdihydrogentriphosphate);CTPNa.2H2O;CYTIDINE 5'-TRIPHOSPHATE DISODIUM SALT 2-HYDRATE;CYTIDINE-5'-TRIPHOSPHATE 2NA 2H2O;dTTP.Na2;-triphosphate(CTP),trisodium salt;Cytidine 5'-triphosphate disodium salt ,98%;5′-CTP,2Na
• CAS NO: 36051-68-0
• Molecular Formula: C9H14N3Na2O14P3
• Molecular Weight: 527.12
• EINECS: 252-849-3
• Product Categories: nucleoside;Material
• Mol File: 36051-68-0.mol

Chemical Properties

• Boiling Point: 849.2oC at 760 mmHg
• Flash Point: 113 °C
• Appearance: White/Powder
• Density: 2.5g/cm3
• Storage Temp.: −20°C
• Solubility: H2O: 50 mg/mL, clear, colorless
• Water Solubility: Soluble in water. Insoluble in ethanol, chloroform and ether.
• CAS DataBase Reference: Cytidine 5'-triphosphate disodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine 5'-triphosphate disodium salt(36051-68-0)
• EPA Substance Registry System: Cytidine 5'-triphosphate disodium salt(36051-68-0)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 36051-68-0(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Reactions:
Cytidine 5'-triphosphate disodium salt is used as a pyrimidine nucleoside triphosphate salt for its involvement in various biochemical reactions, including the synthesis of RNA by RNA polymerases.
Used in Phosphatidylcholine Synthesis:
CTP is used as a reactant in the formation of phosphatidylcholine (PC), where it reacts with phosphocholine via CTP:phosphocholine cytidylyltransferases to produce CDP-choline and diphosphate. This reaction is the rate-limiting step in PC synthesis and plays a crucial role in cell proliferation, which can be significant in cancer development.
Used in Sialylation:
Cytidine 5'-triphosphate disodium salt is used as a reactant in the interaction with N-acylneuraminate, mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate required for sialylation, namely CMP-N-acylneuraminic acid.
Used in Pharmaceutical Applications:
CTP is used as a cation-permeable ligand-gated ion channel (P2X purinergic receptor) agonist and serves as an organic intermediate, pharmaceutical intermediate, food additive, and flavoring agent.
Used in the Food Industry:
Cytidine 5'-triphosphate disodium salt is used as a flavoring agent and additive in the food industry to enhance taste and improve product quality.
Chemical Properties:
Cytidine 5'-triphosphate disodium salt is a white powder with various applications in different industries, including biochemical research, pharmaceuticals, and the food industry.

Pharmacological action

Disodium cytidine triphosphate is a nucleotide derivative. It participates in phospholipid synthesis and metabolism in the body and can pass through the blood-cerebrospinal fluid barrier. It is an intermediate product and energy source between cephalin synthesis and nucleic acid metabolism, and promotes the repair of liver cells after injury , for the myocardial and brain tissue caused by vascular sclerosis, nutrition, promote regeneration and repair.

Biochem/physiol Actions

Cytidine 5′-triphosphate (CTP) prevents the action of aspartate carbamoyltransferase. This enzyme participates in pyrimidine biosynthesis. Like adenosine triphosphate (ATP), CTP serves as a molecule of high energy. It acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.