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362512-44-5

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362512-44-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 362512-44-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,2,5,1 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 362512-44:
(8*3)+(7*6)+(6*2)+(5*5)+(4*1)+(3*2)+(2*4)+(1*4)=125
125 % 10 = 5
So 362512-44-5 is a valid CAS Registry Number.

362512-44-5Relevant articles and documents

Alpidem analogues containing a GABA or glycine moiety as new anticonvulsant agents

Trapani, Giuseppe,Latrofa, Andrea,Franco, Massimo,Carrieri, Antonio,Cellamare, Saverio,Serra, Mariangela,Sanna, Enrico,Biggio, Giovanni,Liso, Gaetano

, p. 231 - 240 (2003)

Alpidem analogues containing a GABA (1-3) or glycine (4-6) moiety were synthesized and their interaction with the GABA/benzodiazepine receptor complex at central (CBR) and peripheral (PBR) level was evaluated. In particular, their ability to modulate the specific binding of [3H]-GABA to washed membrane preparations from the rat cerebral cortex, as well as their effects on human recombinant GABAA receptors in Xenopus laevis oocytes, were assessed. Results from these in vitro assays showed that the most active compounds were 1 and 4. Intraperitoneal administration of compound 1 at a dose of 150 mg/kg significantly antagonized pentylenetetrazole-induced seizures in rats and the protective effects were evident for 90 min. However, compound 4 failed to interact with strychnine-sensitive Gly-binding sites. Consistent with these binding results, intraperitoneal administration of compound 4 at 150 mg/kg showed no effect against convulsions induced by strychnine, except for a prolonged time of the latency of convulsions. The results obtained suggest that compound 1 possesses interesting anticonvulsant activity and deserves further investigation as a novel lipophilic GABA derivative.

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