3627-51-8

Basic information

• Product Name: Monascamine
• Synonyms: Furo[3,2-g]isoquinoline-2,9(7H,9aH)-dione,9amethyl- 3-(1-oxooctyl)-6-(1E)-1-propenyl-,(9aR)-;Monascorubramine
• CAS NO: 3627-51-8
• Molecular Weight: 381.472
• Mol File: 3627-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Monascamine(CAS DataBase Reference)
• NIST Chemistry Reference: Monascamine(3627-51-8)
• EPA Substance Registry System: Monascamine(3627-51-8)

Safety Data

• Hazardous Substances Data: 3627-51-8(Hazardous Substances Data)

Usage

General Description

Monascamine is a natural bioactive compound derived from the Monascus fungus that has been found to have potential pharmacological applications. It is a type of azaphilone molecule and is known for its antioxidative, anti-inflammatory, and antitumor properties. Monascamine has been found to inhibit the growth of cancer cells and reduce the production of inflammatory molecules in the body. Studies have also shown that it may have neuroprotective effects and could potentially be used in the treatment of neurodegenerative diseases. Its ability to modulate the immune response and its potential as a therapeutic agent make it a promising area of research for future drug development.

Upstream product

• 13283-90-4 monascorubrin 

Downstream Products

• 3627-52-9 (9aR)-9ξ-hydroxy-9a-methyl-3-octanoyl-6-trans-propenyl-9,9a-dihydro-7H-furo[3,2-g]isoquinolin-2-one 
• 3627-54-1 3-bromo-3-(2-bromo-octanoyl)-6-(1,2-dibromo-propyl)-9-hydroxy-9a-methyl-9,9a-dihydro-3H-furo[3,2-g]isoquinolin-2-one 
• 3627-52-9 9-hydroxy-9a-methyl-3-octanoyl-6-trans-propenyl-9,9a-dihydro-7H-furo[3,2-g]isoquinolin-2-one 
• 3627-53-0 3-bromo-3-(2-bromo-octanoyl)-6-(1,2-dibromo-propyl)-9a-methyl-3H,9aH-furo[3,2-g]isoquinoline-2,9-dione 

Relevant articles and documents

Sulfonation of Monascus pigments to produce water-soluble yellow pigments

Red Yeast Rice, a kind of Monascus pigments produced by fermentation of Monascus species on rice, is a traditional Chinese medicine and food colorant. Chemical modification of natural pigments is a common strategy to diversify the pigments to meet various demands. Herein, native Monascus pigments as well as some of their derivates were prepared. Sulfonation of Monascus pigments with conjugated double bonds adjacent to a carbonyl group was carried out to produce novel water-soluble yellow pigments (WSYPs). The chemical structure of novel WSYPs, i.e., an addition of H2SO3 to the double bond at the side-chain of Monascus pigments, was elucidated by MS and NMR analysis. The introduction of H2SO3 into Monascus pigments makes WSYPs exhibit yellow color and high water solubility. The yellow color, high water solubility, as well as relatively high stability in a wide pH range contribute the novel WSYPs as a potential food colorant.