364-78-3

Basic information

• Product Name: 4-Fluoro-2-nitrobenzeneamine
• Synonyms: 4-Fluoro-2-nitroaniline,98%;4-FLUORO-2-NITROANILINE;4-FLUORO-2-NITROBENZENEAMINE;2-NITRO-4-FLUOROANILINE;Benzenamine, 4-fluoro-2-nitro-;4-Fluoro-2-Nitroaniline 2-Nitro-4-Fluoroaniline;4-Fluoro-2-nitroaniline 97%;4-Fluoro-2-nitroaniline97%
• CAS NO: 364-78-3
• Molecular Formula: C₆H₅FN₂O₂
• Molecular Weight: 156.11
• EINECS: 206-666-0
• Product Categories: Chemical Synthesis;Fluorinated Building Blocks;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Anilines, Aromatic Amines and Nitro Compounds;Anilines, Amides & Amines;Fluorine Compounds;Nitro Compounds;Amines;C2 to C6;Nitrogen Compounds;Fluorinated benzene series;Aryl Fluorinated Building Blocks;Building Blocks;C6
• Mol File: 364-78-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 90-94 °C(lit.)
• Boiling Point: 295.1 °C at 760 mmHg
• Flash Point: 193 °F
• Appearance: Orange to brown/Crystalline Powder
• Density: 1.3822 (estimate)
• Vapor Pressure: 1.04mmHg at 25°C
• Refractive Index: 1.472
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -0.11±0.10(Predicted)
• Water Solubility: INSOLUBLE
• BRN: 2210197
• CAS DataBase Reference: 4-Fluoro-2-nitrobenzeneamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-nitrobenzeneamine(364-78-3)
• EPA Substance Registry System: 4-Fluoro-2-nitrobenzeneamine(364-78-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-36/37/39
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 364-78-3(Hazardous Substances Data)

Usage

Chemical Properties

orange to brown crystalline powder

Uses

Different sources of media describe the Uses of 364-78-3 differently. You can refer to the following data:
1. 4-Fluoro-2-nitroaniline is used as a reagent in the preparation of 4-fluoro-o-phenylenediamine, 4-fluoro-N-ethyl-2-nitroaniline and N-(4-fluoro-2-nitrophenyl)-beta-alanine. It is also employed as a pharmaceutical intermediate. It acts as monodendate O-bonded ligand used in the coordination chemistry to form complexes with copper(II), nickel(II) and cobalt(II).
2. 4-Fluoro-2-nitroaniline was used as starting reagent in the synthesis of 4-fluoro-N-ethyl-2-nitroaniline and N-(4-fluoro-2-nitrophenyl)-β-alanine.

General Description

4-Fluoro-2-nitroaniline forms complexes with cobalt(II), nickel(II) and copper(II).

InChI:InChI=1/C8H6F2O/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,1H3

Upstream product

• 402-67-5 3-fluoro-1-nitrobenzene 
• 110-91-8 morpholine 
• 448-39-5 N-(4-fluoro-2-nitrophenyl)acetamide 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 540-36-3 para-difluorobenzene 
• 371-40-4 4-fluoroaniline 
• 351-83-7 4'-fluoroacetanilide 
• 893620-80-9 N-(4-fluorophenyl)pyrimidin-2-ylamine 

Downstream Products

• 10472-88-5 4-fluoro-2-bromo-6-nitroaniline 
• 143948-69-0 ethyl 3-[(4-fluoro-2-nitrophenyl)amino]-3-oxopropionate 
• 328546-72-1 3-[(4-fluoro-2-nitrophenyl)amino]propanenitrile 
• 74916-51-1 3-amino-7-fluoro-1,2,4-benzotriazine-1-oxide 
• 149440-45-9 5-fluoro-2,1,3-benzoxadiazole 
• 6124-22-7 5-Dimethylamino-benzofurazan 
• 36389-16-9 5-Fluorobenzofuroxan 
• 866417-37-0 7-[4-(2-carboxy-phenylcarbamoyloxymethyl)-imidazol-1-yl]-3-ethoxy-6-nitro-quinoxaline-2-carboxylic acid ethyl ester 
• 866417-38-1 7-[4-(4-carboxy-phenylcarbamoyloxymethyl)-imidazol-1-yl]-3-ethoxy-6-nitro-quinoxaline-2-carboxylic acid ethyl ester 
• 1000815-27-9 ethyl 8-bromo-5-fluoro-4-hydroxyquinoline-3-carboxylate 
• 1003-99-2 2-bromo-5-fluoroaniline 
• 78568-58-8 5-fluoro-2-phthalimidonitrobenzene 
• 440116-79-0 6-fluoro-2,3-bis(4-methylphenyl)quinoxaline 

Relevant articles and documents

HETEROCYCLIC SYSTEMS CONTAINING BRIDGEHEAD NITROGEN ATOMS. PART LXVIII. REACTION OF 5-FLUOROBENZIMIDAZOLYL-2-THIONE WITH CHLOROACETIC ACID: STUDIES OF ORIENTATION OF CYCLIZATION IN THE SYNTHESES OF 6-FLUORO- AND 7-FLUOROTHIAZOLOBENZIMIDAZOL-3(2H)-ONES

4-Fluoroaniline on successive acetylation, nitration and hydrolysis affords 4-fluoro-2-nitroaniline which on reduction with Raney nickel and hydrazine hydrate followed by treatment of the resulting diamine with carbon disulphide in situ gives 5-fluorobenzimidazolyl-2-thione.The thione on condensation with chloroacetic acid yields acetic acid which on cyclization in a mixture of acetic anhydride and pyridine furnishes two isomers viz. 6-fluoro- and 7-fluorothiazolobenzimidazol-3(2H)-ones.The condensation of thione with 1,2-dibromoethane affords sym-bis-(5-fluorobenzimidazo-2-yl-mercapto)ethane.The structural assignments for the 6-fluoro- and 7-fluorothiazolobenzimidazol-3(2H)-ones have been made by 1H-NMR spectral data using two different methods.

A preparation method for 4-methoxy-2-nitrobenzoic acid

An industrial preparation method for 4-methoxy-2-nitrobenzoic acid is disclosed. In the method, p-difluorobenzene is adopted as an initial raw material and subjected to nitration, ammonolysis, diazotization bromination, cyaniding, methoxylation and hydrolysis which are six steps to synthesize the 4-methoxy-2-nitrobenzoic acid. The 4-methoxy-2-nitrobenzoic acid obtained by the method is white powdered solid with purity being 98.5%, the raw material conversion ratio in each step is 100%, and the total yield of the whole process is 35.8%.

Harnessing the pyrroloquinoxaline scaffold for FAAH and MAGL interaction: Definition of the structural determinants for enzyme inhibition

This paper describes the development of piperazine and 4-aminopiperidine carboxamides/carbamates supported on a pharmacogenic pyrroloquinoxaline scaffold as inhibitors of the endocannabinoid catabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). Structure-activity relationships and molecular modelling studies allowed the definition of the structural requirements for dual FAAH/MAGL inhibition and led to the identification of a small set of derivatives (compounds 5e, i, k, m) displaying a balanced inhibitory profile against both enzymes, with compound 5m being the frontrunner of the subset. Favorable calculated physico-chemical properties suggest further investigation for specific analogues.