3646-73-9

Basic information

• Product Name: C00984
• Synonyms: alpha-D-Galactose;C00984
• CAS NO: 3646-73-9
• Molecular Formula: C₆H₁₂O₆
• Molecular Weight: 180.15588
• Product Categories: Carbohydrates & Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 3646-73-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 410.8°Cat760mmHg
• Flash Point: 202.2°C
• Appearance: /
• Density: 1.732g/cm³
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Water (Slightly)
• CAS DataBase Reference: C00984(CAS DataBase Reference)
• NIST Chemistry Reference: C00984(3646-73-9)
• EPA Substance Registry System: C00984(3646-73-9)

Safety Data

• Hazardous Substances Data: 3646-73-9(Hazardous Substances Data)

Usage

Uses

α-D-Galactose is the alpha anomer of D-Galactose (G155250), the C-4 epimer of Glucose (G595000). D-Galactose is found in milk and sugar beets as well as being synthesized by the body.

Purification Methods

-D-Galactose is crystallised twice from aqueous 80% EtOH at -10o, then dried in a vacuum oven at 90o over P2O5 for 10hours. [Link Biochemical Preparations 3 75 1953, Hansen et al. Biochemical Preparations 4 2 1955.] Also purify it by recrystallising the dried solid (150g) in hot H2O (150mL), then adding hot MeOH (250mL) and hot EtOH (500mL), stirring to mix, filtering through a bed of charcoal, and the clear filtrate is stirred to initiate crystallisation. After standing overnight at 10o, the crystals of the -anomer are filtered off by suction, washed with MeOH, then EtOH, and dried (yield 130g), and more can be obtained by evaporation of the filtrate and washing as before. [Wolfrom & Thompson Methods in Carbohydrate Chemistry I 120 1962, Academic Press, Beilstein 1 IV 4336.]

Upstream product

• 81720-06-1 rehmannioside B 
• 7493-95-0 4-nitrophenyl α-D-galactoside 
• 499-40-1 melibiose 
• 369-07-3 o-nitrophenyl-α-D-galactopyranoside 
• 76951-66-1 1,2:3,4-di-O-isopropylidene-6-O-trityl-α-D-galactopyranose 
• 2816-24-2 o-nitrophenyl D-galactopyranoside 
• 56763-10-1 2-chloroethyl 1-thio-β-D-galactopyranoside 
• 512-69-6 D-raffinose 
• 470-55-3 stachyose 

Downstream Products

• 24822-33-1 D-isomaltose 
• 57-50-1 Sucrose 
• 1769-00-2 1,2,3,4,6-penta-O-trimethylsilyl-α-D-galactose 
• 4064-06-6 1,2:3,4-di-O-isopropylidene-α-D-galactopyranose 
• 60945-45-1 O¹,O²-isopropylidene-O³,O⁴-phenylboranediyl-α-D-galactopyranose 
• 2592-58-7 1,2,3,4,6-penta-O-benzoyl-α-D-galactopyranoside 
• 15038-71-8 2-benzyl,3-hydroxy,4,6-benzylidene acetal-β-methyl galactopyranose 
• 15038-69-4 methyl 2-O-benzyl-β-D-galactopyranoside 
• 20275-00-7 galactose oxime 
• 250358-67-9 2'-thioethyl-α-D-galactopyranoside 
• 4478-43-7 (1,2:3,4-di-O-isopropylidene-6-O-(p-toluensulfonate))-D-galactopiranose 
• 139974-84-8 phenyl 2,3,4,6-tetra-O-benzyl-1-thio-α-D-galactopyranoside 

Relevant articles and documents

Structural determination of a neutral exopolysaccharide produced by Lactobacillus delbrueckii ssp. bulgaricus LBB.B332

The neutral exopolysaccharide produced by Lactobacillus delbrueckii ssp. bulgaricus LBB.B332 in skimmed milk was found to be composed of d-glucose, d-galactose, and l-rhamnose in a molar ratio of 1:2:2. Linkage analysis and 1D/2D NMR (1H and 13C) studies carried out on the native polysaccharide as well as on an oligosaccharide generated by a periodate oxidation protocol, showed the polysaccharide to consist of linear pentasaccharide repeating units with the following structure:{A figure is presented}.

Acylated iridoid glycosides with hyaluronidase inhibitory activity from the rhizomes of Picrorhiza kurroa Royle ex Benth

Seven new acylated iridoid glycosides, picrorhizaosides A–G (1–7), were isolated from the methanol extract of the rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae), in addition to six known iridoid glycosides (8–13). The structures of these new iridoids, including their stereochemistry, were determined based on chemical and physicochemical evidence derived from NMR and MS analysis. Of the isolates, picrorhizaosides D (4, IC50 = 43.4 μM) and E (5, 35.8 μM); picrosides I (8, 60.7 μM), II (9, 22.3 μM), and IV (11, 59.2 μM); and minecoside (13, 57.2 μM), exhibited a similar or stronger hyaluronidase inhibitory activity than those of the antiallergic medicines disodium cromoglycate (64.8 μM), ketotifen fumarate (76.5 μM), and tranilast (227 μM).

Arabinogalactan hydrolysis and hydrolytic hydrogenation using functionalized carbon materials

Hydrolysis of the hemicellulose arabinogalactan was studied in this work over several functionalized carbon materials, which were specifically treated to increase their acidities. Hydrolytic hydrogenation of arabinogalactan was investigated using the same materials in a mechanical mixture with ruthenium supported on active carbon. Application of these mixtures resulted in formation of polyols, suppressing simultaneously the generation of side products hydroxymethylfurfural (HMF) and furfural. Formation of high molecular weight compounds (aggregates of sugars and humins) was still quite substantial with a mechanical mixture of Ru/C and a carbon material prepared from sucrose by activation with zinc chloride to increase porosity. Post-treatment of this carbonaceous material with sulphuric acid significantly influenced kinetics of high molecular weight products formation resulting also in elevation of sugar alcohols yields.