36480-40-7

Basic information

• Product Name: 3,4-DICHLOROBENZYL MERCAPTAN
• Synonyms: 3,4-DICHLOROBENZENEMETHANETHIOL;3,4-DICHLOROBENZYL MERCAPTAN;(3,4-Dichlorophenyl)methanethiol;Benzenemethanethiol, 3,4-dichloro-;3,4-dichlorotoluene-alpha-thiol;3,4-Dichloro-alpha-toluenethiol;3,4-dichloro-à-toluenethiol
• CAS NO: 36480-40-7
• Molecular Formula: C₇H₆Cl₂S
• Molecular Weight: 193.09
• EINECS: 253-054-4
• Mol File: 36480-40-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 152-153°C 12mm
• Flash Point: 152-153°C/12mm
• Appearance: /
• Density: 1.362
• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.6080
• PKA: 8.83±0.10(Predicted)
• Water Solubility: Difficult to mix in water.
• Sensitive: Air Sensitive
• BRN: 3237473
• CAS DataBase Reference: 3,4-DICHLOROBENZYL MERCAPTAN(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DICHLOROBENZYL MERCAPTAN(36480-40-7)
• EPA Substance Registry System: 3,4-DICHLOROBENZYL MERCAPTAN(36480-40-7)

Safety Data

• Statements: 20/21/22
• Safety Statements: 23-36/37
• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 36480-40-7(Hazardous Substances Data)

Usage

Uses

Reatant in the synthesis of substituted pyridazines. 3,4-Dichlorobenzyl mercaptan helps to improve the semiconductor morphologies.

InChI:InChI=1/C7H6Cl2S/c8-6-2-1-5(4-10)3-7(6)9/h1-3,10H,4H2

Upstream product

• 29023-36-7 dimethyl-dithiocarbamic acid-(3,4-dichloro-benzyl ester) 
• 23566-18-9 1,1'-bis<3,4-dichlorobenzene> 
• 102-47-6 3,4-Dichlorophenylmethyl chloride 
• 17356-08-0 thiourea 
• 22297-13-8 S-(3,4-dichlorobenzyl)isothiourea 
• 131887-65-5 [(3,4-Dichloro-benzylsulfanyl)-dimethylamino-methylene]-dimethyl-ammonium; iodide 
• 22816-60-0 S-(3,4-dichlorobenzyl)isothiourea hydrochloric acid salt 

Downstream Products

• 124880-20-2 1-[(4-chlorobutyl)thiomethyl]-3,4-dichlorobenzene 
• 75663-55-7 4-(2-fluorophenyl)-1,2,3,6-tetrahydro-1-methylpyridine 
• 72364-17-1 4-(3,4-Dichloro-benzylsulfanyl)-4-(2-fluoro-phenyl)-1-methyl-piperidine 
• 213533-31-4 (R)-2-(Benzyl-benzyloxycarbonyl-amino)-3-(3,4-dichloro-benzylsulfanyl)-propionic acid 
• 820244-54-0 (1R,2S,3R,5R,6R)-2-azido-3-(3,4-dichlorobenzylsulfanyl)-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester 
• 63198-16-3 1-[2-(3,4-dichloro-benzylsulfanyl)-4-phenyl-butyl]-1H-imidazole 
• 1039753-07-5 4-[(3,4-dichlorobenzyl)thio]-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Relevant articles and documents

Synthesis and Biological Activity of trans-(+/-)-N-Methyl-2-(3-pirydyl)-2-tetrahydrothiopyrancarbothioamide 1-Oxide (RP 49356) and Analogues: A New Class of Potassium Channel Opener

The synthesis and biological activity of trans-(+/-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (8a, RP 49356) and analoques is reported.These compounds constitute a new structural class of K+-channel opener.The effects of changes in the pyridyl group, thioamide, and thiane ring on in vitro K+-channel opening activity are discussed.A 3-pyridyl or 3-quinolyl group, a small N-alkyl thioamide function, and a thiane oxide ring, in which the sulfoxide is in a trans relationship to thioamide, are preferred for activity.Selected compounds were tested intravenously in the normotensive anaesthetized rat for hypotensive effects, and the activities reflect their in vitro K+-channel opening activity.This led to further evaluation of compound 8a and the selection of the (-)-enantiomer 8b (RP 52891) for development as an antihypertensive and antianginal agent.

Synthesis of certain derivatives of thiols.

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