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36598-30-8

36598-30-8

Identification

Synonyms:Benzylpotassium cyanimidodithiocarbonate; Benzyl potassium cyanoimidodithiocarbonate;Potassium benzyl cyanodithioimidocarbonate; Potassium benzylcyanoimidodithiocarbonate

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTERS-POTASSIUM SALT 95.00%
  • Packaging:10G
  • Price:$ 1190.92
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:CYANIMIDODITHIOCARBONIC ACID S-BENZYL ESTERS-POTASSIUM SALT 95.00%
  • Packaging:1G
  • Price:$ 643.98
  • Delivery:In stock
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Relevant articles and documentsAll total 1 Articles be found

Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability to Rescue Auditory Gating Deficit in Mice

Li, Yuanheng,Sun, Lilan,Yang, Taoyi,Jiao, Wenxuan,Tang, Jingshu,Huang, Xiaomin,Huang, Zongze,Meng, Ying,Luo, Laichun,Wang, Xintong,Bian, Xiling,Zhang, Fang,Wang, Kewei,Sun, Qi

, p. 159 - 173 (2019/01/15)

A series of novel thiazolo[4,5-d]pyrimidin-7(6H)-ones (3aa-3eq) were designed, synthesized, and evaluated as the type I positive allosteric modulators of human α7 nAChR expressed in Xenopus ooctyes by a two-electrode voltage clamp. The structure-activity relationship analysis identified the compound 3ea as a potent and efficacious PAM with the maximum activation effect of the α7 current of over 1633% in the presence of acetylcholine (100 μM) and an EC50 = 1.26 μM. It is highly specific to α7 nAChR over other subtypes of nAChR, 5-HT3A, NMDA, and GABAA receptors. Compound 3ea showed an elimination half-life of 10.8 ± 1.5 h for 3 mg/kg, i.v., and 7.4 ± 1.1 h for 60 mg/kg, i.g. in rat. It also exhibited sufficient blood-brain barrier penetration with no significant effect on hERG channel. Most importantly, compound 3ea dose-dependently (0.1-1 mg/kg, i.p.) reversed the prepulse inhibition deficit induced by MK-801 in the mouse schizophrenia model.

Process route upstream and downstream products

Process route

benzyl bromide
100-39-0

benzyl bromide

potassium cyanocarbonimidodithioate
13145-41-0

potassium cyanocarbonimidodithioate

cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

Conditions
Conditions Yield
In acetone; at 0 - 20 ℃; for 6h;
97%
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

Conditions
Conditions Yield
K-Salz 2, CH3Br;
K-Salz 2, CH3I;
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

chloroacetonitrile
107-14-2

chloroacetonitrile

4-amino-2-(benzylthio)thiazole-5-carbonitrile
39736-35-1

4-amino-2-(benzylthio)thiazole-5-carbonitrile

Conditions
Conditions Yield
With triethylamine; In ethanol; acetone; at 70 ℃; for 4h;
72%
Multistep reaction; (i) EtOH, (ii) Et3N;
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

3-chloro-5-phenylmethanesulfonyl-[1,2,4]thiadiazole
36950-21-7

3-chloro-5-phenylmethanesulfonyl-[1,2,4]thiadiazole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: SO2Cl2 / CHCl3 / 3.5 h / Heating
2: MCPBA / CHCl3 / 3 h / Ambient temperature
With sulfuryl dichloride; 3-chloro-benzenecarboperoxoic acid; In chloroform;
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

3-chloro-5-phenylmethanesulfinyl-[1,2,4]thiadiazole
36950-14-8

3-chloro-5-phenylmethanesulfinyl-[1,2,4]thiadiazole

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: SO2Cl2 / CHCl3 / 3.5 h / Heating
2: H2O2 / acetic acid; acetic anhydride / 48 h / Ambient temperature
With sulfuryl dichloride; dihydrogen peroxide; In chloroform; acetic anhydride; acetic acid;
2,3-bis(bromomethyl)quinoxaline
3138-86-1

2,3-bis(bromomethyl)quinoxaline

cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

2,3-Bis<<(benzylthio)(cyanimino)methyl>thiomethyl>chinoxalin
85219-60-9

2,3-Bis<<(benzylthio)(cyanimino)methyl>thiomethyl>chinoxalin

Conditions
Conditions Yield
In chloroform; acetone; for 24h; Ambient temperature;
80%
2,3,4,6-tetra-O-benzoylglucosyl bromide
14218-11-2

2,3,4,6-tetra-O-benzoylglucosyl bromide

cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

Benzyl-N-cyan(tetra-O-benzoyl-β-D-glucopyranosyl)dithiocarbimidat
85219-52-9

Benzyl-N-cyan(tetra-O-benzoyl-β-D-glucopyranosyl)dithiocarbimidat

Conditions
Conditions Yield
In acetone; for 8h; Heating;
70%
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

methyl chloroacetate
96-34-4

methyl chloroacetate

4-amino-2-benzylsulfanyl-thiazole-5-carboxylic acid methyl ester
59972-74-6

4-amino-2-benzylsulfanyl-thiazole-5-carboxylic acid methyl ester

Conditions
Conditions Yield
With triethylamine; In acetone;
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

2-Benzylsulfanyl-5,7-dichloro-thiazolo[4,5-d]pyrimidine
87789-39-7

2-Benzylsulfanyl-5,7-dichloro-thiazolo[4,5-d]pyrimidine

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 2) Et3N / 1) ethanol, 30 min, reflux, 2) 5 min, reflux
2: 180 - 200 °C
3: POCl3 / various solvent(s) / 3 h / Heating
With triethylamine; trichlorophosphate; In various solvent(s);
cyano-dithiocarbamic acid benzyl ester; potassium salt
36598-30-8

cyano-dithiocarbamic acid benzyl ester; potassium salt

5-benzylsulfanyl-3-chloro-[1,2,4]thiadiazole
36598-31-9

5-benzylsulfanyl-3-chloro-[1,2,4]thiadiazole

Conditions
Conditions Yield
With sulfuryl dichloride; In chloroform; for 3.5h; Heating;

Global suppliers and manufacturers

Global( 4) Suppliers
  • Company Name
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  • Antimex Chemical Limied
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-21-50563169
  • Emails:anthony@antimex.com
  • Main Products:163
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:1
  • Country:China (Mainland)
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