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36635-56-0

36635-56-0

Identification

Synonyms:N-(Tosylmethyl)formamide;N-(p-Toluenesulfonylmethyl)formamide;

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH351 Suspected of causing cancer

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:AK Scientific
  • Product Description:N-(p-Tolylsulfonylmethyl)formamide
  • Packaging:10g
  • Price:$ 937
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:N-(P-TOLYL SULFONYL METHYL) FORMAMIDE 95.00%
  • Packaging:5MG
  • Price:$ 497.48
  • Delivery:In stock
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  • Manufacture/Brand:Atlantic Research Chemicals
  • Product Description:N-(p-Tolylsulphonylmethyl)formamide 95%
  • Packaging:1gm:
  • Price:$ 279.23
  • Delivery:In stock
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  • Manufacture/Brand:Chemenu
  • Product Description:N-(Tosylmethyl)formamide 95+%
  • Packaging:1g
  • Price:$ 380
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:N-(Tosylmethyl)formamide 97%
  • Packaging:1g
  • Price:$ 402
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:N-(p-Tolylsulfonylmethyl)formamide 95%
  • Packaging:1g
  • Price:$ 570
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:N-(p-Tolylsulfonylmethyl)formamide
  • Packaging:500mg
  • Price:$ 295
  • Delivery:In stock
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Relevant articles and documentsAll total 12 Articles be found

Br?nsted Acid Organocatalyzed Three-Component Hydroamidation Reactions of Vinyl Ethers

Smajlagic, Ivor,Carlson, Brenden,Dudding, Travis

, p. 4171 - 4181 (2021)

Hydroamidation of carbon-carbon double bonds is an attractive strategy for installing nitrogen functionality into molecular scaffolds and, with it, increasing molecular complexity. To date, metal-based approaches have dominated this area of chemical synth

Phenyl pyrrole compound and application thereof in bactericidal activity

-

Paragraph 0137; 0139, (2020/08/17)

The invention provides a novel phenyl pyrrole compound, and the phenyl pyrrole compound shows good bactericidal activity and can be used for preparing a broad-spectrum plant bactericide. In addition,the synthesis route is simple, the operation is convenient, the synthesis cost is reduced, and ecological environment pollution to soil, surface water, underground water and the like is avoided.

A 2-fluoro-4-methyl sulfonyl methyl isonitriles method for the synthesis of

-

Paragraph 0021; 0022, (2017/03/08)

The invention discloses a synthesis method of 2-fluoro-4-toluenesulfonylmethyl isocyanide. The method comprises the following steps: with sodium p-tolylsulfinate as a raw material, carrying out similar Mannich condensation and amide dehydration reaction to prepare tolylsulfonylmethyl isocyanide; adding a hydrofluoric acid aqueous solution and an Ni-CO catalyst to tolylsulfonylmethyl isocyanide; and fully reacting under nitrogen protection, and carrying out suction filtration, washing and drying to obtain faint yellow crystal 2-fluoro-4-toluenesulfonylmethyl isocyanide, wherein the yield reaches over 92%, and the purity is 99.8%. The synthesis method has the advantages of being available in reaction raw materials, mild in condition, high in yield, suitable for industrial production and the like.

Process route upstream and downstream products

Process route

[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

benzaldehyde
100-52-7

benzaldehyde

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

2-hydroxy-2-phenylacetophenone
119-53-9,579-44-2

2-hydroxy-2-phenylacetophenone

N-(tosylmethyl)-2-hydroxy-2-phenylacetamide

N-(tosylmethyl)-2-hydroxy-2-phenylacetamide

Conditions
Conditions Yield
[(p-methylphenyl)sulfonylmethyl]isonitrile; benzaldehyde; With pyridine N-oxide; tetrachlorosilane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -74 ℃; for 24h;
With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 2h;
7%
64%
16%
sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
With formic acid; at 90 ℃; for 2h;
90%
formaldehyd; formamide; sodium 4-methylbenzenesulfinate; With formic acid; at 90 ℃; for 2h;
With sodium chloride; at 20 ℃; for 2h; Cooling with ice;
61%
With formic acid;
With formic acid; at 90 ℃; for 16h;
With formic acid; at 90 ℃; for 2h;
With sodium hydroxide; at 60 - 100 ℃; for 4h; Temperature;
181 g
sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
With formic acid; formamide; paraformaldehyde; In water;
With formic acid; formamide; paraformaldehyde; In water;
With formic acid; formamide; paraformaldehyde; In water;
formic acid
64-18-6

formic acid

sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
at 90 ℃; for 2h;
78.1%
[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
With water; copper(II) bis(trifluoromethanesulfonate); In toluene; at 70 ℃; Reagent/catalyst; Schlenk technique; Inert atmosphere;
81%
[(p-methylphenyl)sulfonylmethyl]isonitrile
38622-91-2,36635-61-7

[(p-methylphenyl)sulfonylmethyl]isonitrile

ethyl vinyl ether
109-92-2,25104-37-4

ethyl vinyl ether

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

2-ethoxy-N-(tosylmethyl)propanamide

2-ethoxy-N-(tosylmethyl)propanamide

Conditions
Conditions Yield
With camphor-10-sulfonic acid; water; In tetrahydrofuran; at 20 ℃; for 5h;
para-thiocresol
106-45-6

para-thiocresol

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N-Bromosuccinimide / dichloromethane / 1 h / 0 °C
2: formic acid; toluene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation
With N-Bromosuccinimide; In formic acid; dichloromethane; toluene;
methyl p-toluene sulfinate
672-78-6

methyl p-toluene sulfinate

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
In formic acid; toluene; at 100 ℃; for 3h; Inert atmosphere; Microwave irradiation;
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium sulfite; sodium hydrogencarbonate / water / 1 h / 70 - 80 °C
2: 2 h / 90 °C
With sodium hydrogencarbonate; sodium sulfite; In water;
N-(4-methylbenzenesulfonylmethyl)-formamide
36635-56-0

N-(4-methylbenzenesulfonylmethyl)-formamide

Conditions
Conditions Yield
Na-p-Toluolsulfonat, Formaldehyd, Formamid;

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