3664-87-7Relevant articles and documents
Reduction of 3α-hydroxy-5β-chol-6-en-24-oic acid to lithocholic acid in rats
Kimura, Koji,Ogura, Michio
, p. 337 - 348 (1988)
After Δ6-lithocholic acid was injected into the cecum of rats, lithocholic acid was identified as a metabolite in feces.When the labeled Δ6-bile acid was injected intraperitoneally into bile-fistula rats, radioactivity excreted in bile was contained most abundantly in the taurine-conjugated fraction of bile acids.In the fraction, taurine conjugate of Δ6-lithocholic acid but of neither lithocholic acid nor other bile acids was found.The results showed that Δ6-lithocholic acid was reduced to lithocholic acid by intestinal flora but not by the liver, which, however, was capable of conjugating Δ6-lithocholic acid with taurine.