366452-98-4

Basic information

• Product Name: 4-AMINOISOINDOLIN-1-ONE
• Synonyms: 4-AMINOISOINDOLIN-1-ONE;1H-Isoindol-1-one, 4-amino-2,3-dihydro- (9CI);1H-Isoindol-1-one, 4-aMino-2,3-dihydro-;4-amino-2,3-dihydro-1H-isoindol-1-one;4-Amino-2,3-dihydro-isoindol-1-one
• CAS NO: 366452-98-4
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Product Categories: ALCOHOL;AMINEPRIMARY
• Mol File: 366452-98-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 225-230°
• Boiling Point: 489.776 °C at 760 mmHg
• Flash Point: 250.008 °C
• Appearance: /
• Density: 1.307 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.24±0.20(Predicted)
• CAS DataBase Reference: 4-AMINOISOINDOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOISOINDOLIN-1-ONE(366452-98-4)
• EPA Substance Registry System: 4-AMINOISOINDOLIN-1-ONE(366452-98-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 366452-98-4(Hazardous Substances Data)

Usage

Uses

4-Aminoisoindolin-1-one is s a reactant that has been used in the synthesis of 4-(N-acyl)-2,3-dihydro-1H-isoindol-1-ones as potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

Upstream product

• 825655-17-2 2-(azidomethyl)-3-nitrobenzoic acid methyl ester 
• 1333-74-0 hydrogen 
• 39830-63-2 3-hydroxy-4-nitroisoindolin-1-one 
• 603-62-3 4-nitro-1H-isoindole-1,3(2H)-dione 
• 98475-07-1 2-bromomethyl-3-nitro-benzoic acid methyl ester 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 366452-97-3 4-nitroisoindolin-1-one 

Downstream Products

• 618445-34-4 N-(3-((((2R)-1-Methyl-2-pyrrolidinyl)methyl)oxy)-4-(trifluoromethyl)phenyl)-2-((1-oxo-2,3-dihydro-1H-isoindol-4-yl)amino)-3-pyridinecarboxamide 
• 850462-71-4 4-{[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)-pentylidene]amino}2,3-dihydroisoindol-1-one 
• 366454-36-6 EB-47 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Small Molecule Microarray Based Discovery of PARP14 Inhibitors

Poly(ADP-ribose) polymerases (PARPs) are key enzymes in a variety of cellular processes. Most small-molecule PARP inhibitors developed to date have been against PARP1, and suffer from poor selectivity. PARP14 has recently emerged as a potential therapeutic target, but its inhibitor development has trailed behind. Herein, we describe a small molecule microarray-based strategy for high-throughput synthesis, screening of >1000 potential bidentate inhibitors of PARPs, and the successful discovery of a potent PARP14 inhibitor H10 with >20-fold selectivity over PARP1. Co-crystallization of the PARP14/H10 complex indicated H10 bound to both the nicotinamide and the adenine subsites. Further structure–activity relationship studies identified important binding elements in the adenine subsite. In tumor cells, H10 was able to chemically knockdown endogenous PARP14 activities.

SUBSTITUTED ARYL-AMINE DERIVATIVES AND METHODS OF USE

The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo-2,3-dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4-dihydro-1,4-benzoxazin-6-yl, 2,2-difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C1-6 alkyl, C2-8 alkenyl, C2-8 alkynyl, N-dimethylamino-C1-6-alkyl, N-dimethylamino-C1-6-alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl,4 morpholinyl, carboxyl, cyano, and acetyl; wherein R1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R1 in formula II is selected from specific bicyclic heterocycles.