36695-15-5Relevant articles and documents
In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative
Amparo, Tatiane R.,Antunes, Amanda S.,Cazati, Thiago,Diogo, Gabriela M.,Dos Santos, Viviane M. R.,Gouveia, Ana Paula,Penido, Ricardo G.,Perasoli, Fernanda B.,Sousa, Lucas R. D.,Taylor, Jason G.,Vieira, Paula M. A.,dos Santos, Orlando D. H.
, p. 1813 - 1821 (2021/08/05)
Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass
Aldose reductase inhibitors for diabetic complications: Receptor induced atom-based 3D-QSAR analysis, synthesis and biological evaluation
Vyas, Bhawna,Singh, Manjinder,Kaur, Maninder,Bahia, Malkeet Singh,Jaggi, Amteshwar Singh,Silakari, Om,Singh, Baldev
supporting information, p. 59 - 71 (2015/05/05)
Herein, atom-based 3D-QSAR analysis was performed using receptor-guided alignment of 46 flavonoid inhibitors of aldose reductase (ALR2) enzyme. 3D-QSAR models were generated in PHASE programme, and the best model corresponding to PLS factor four (QSAR4), was selected based on different statistical parameters (i.e., Rtrain2, 0.96; Qtest2 0.81; SD, 0.26). The contour plots of different structural properties generated from the selected model were utilized for the designing of five new congener molecules. These designed molecules were duly synthesized, and evaluated for their in vitro ALR2 inhibitory activity that resulted in the micromolar (IC50 22 μM) activity of all molecules. Thus, the newly designed molecules having ALR inhibitory potential could be employed for the management of diabetic complications.
Efficient synthesis of nitroflavones by cyclodehydrogenation of 2prime;-hydroxychalcones and by the Baker-Venkataraman method
Barros, Ana I. R. N. A.,Silva, Artur M. S.
, p. 1505 - 1528 (2007/10/03)
Several nitroflavone derivatives were synthesized by cyclodehydrogenation of 2′-hydroxychalcones and by the Baker-Venkataraman approach, starting from 2′-hydroxyacetophenones and benzoic acid derivatives. Nitroflavones synthesised by the first synthetic a
