36821-26-8

Basic information

• Product Name: 2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTE;2-oxopyrrolidine-3-carboxylic acid ethyl ester, ethyl 2-oxo-3-pyrrolidinecarboxylate, ethyl 2-oxopyrrolidine-3-carboxylate, 2-carboethoxy-2-pyrrolidone, 2-oxo-pyrrolidine-3-carboxylic acid ethyl ester, 2-Oxo-pyrrolidin-3-carbonsaeure-aethylester, 2-oxopyrrolidin-3-carboxylic acid ethyl;3-Pyrrolidinecarboxylicacid, 2-oxo-, ethyl ester;2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER;Ethyl2-oxopyrrolidine-3-carboxylate
• CAS NO: 36821-26-8
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• Mol File: 36821-26-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 71-75℃
• Boiling Point: 312.7°Cat760mmHg
• Flash Point: 142.9°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 0.000519mmHg at 25°C
• Refractive Index: 1.466
• Storage Temp.: 2-8°C
• PKA: 15.27±0.20(Predicted)
• Water Solubility: Slightly soluble in water.
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER(36821-26-8)
• EPA Substance Registry System: 2-OXO-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER(36821-26-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 36821-26-8(Hazardous Substances Data)

Usage

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis Reference(s)

Synthetic Communications, 20, p. 2335, 1990 DOI: 10.1080/00397919008053177Tetrahedron Letters, 27, p. 1031, 1986 DOI: 10.1016/S0040-4039(86)80040-5

InChI:InChI=1/C7H11NO3/c1-2-11-7(10)5-3-4-8-6(5)9/h5H,2-4H2,1H3,(H,8,9)

Upstream product

• 105-53-3 diethyl malonate 
• 188528-95-2 1-(tert-butyl) 3-ethyl 2-oxopyrrolidine-1,3-dicarboxylate 
• 17109-93-2 α-cyanomethylmalonic acid diethyl ester 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 

Downstream Products

• 56-12-2 4-amino-n-butyric acid 
• 68074-14-6 3-methylidene-2-oxo-piperidine 
• 76220-95-6 3-methylene-2-pyrrolidinone 
• 1190392-04-1 3-methyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]-triazole-7-carboxylic acid 
• 960299-39-2 1-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-fluorophenyl)-2-oxopyrrolidine-3-carboxylic acid 

Relevant articles and documents

PYRROLIDINONE COMPOUNDS

The present invention provides a compound which is of formula (II), wherein X is selected from the group consisting of (X) or a pharmaceutically acceptable salt thereof, methods for treating obesity, providing therapeutic weight loss, and compositions.

1-(2H)-ISOQUINOLONE DERIVATIVE

The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.