369-26-6Relevant articles and documents
Oridonin derivatives as potential anticancer drug candidates triggering apoptosis through mitochondrial pathway in the liver cancer cells
Luo, Dongdong,Yi, Yujiao,Peng, Kai,Liu, Tangrong,Yang, Jiayu,Liu, Shan,Zhao, Wanzhou,Qu, Xianjun,Yu, Wengong,Gu, Yuchao,Wan, Shengbiao
, p. 365 - 379 (2019/06/17)
The biological function of the natural ent-kaurene diterpenoid isolated from genus Isodon, oridonin, has been intensively studied. However, its mechanism studies and clinical applications were hampered by its moderate biological activities. In order to en
FUSED BICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE
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Paragraph 00196; 00229, (2019/03/05)
Fused bicyclic compounds and uses thereof in medicine. In particular, provided are fused bicyclic compounds used as ASK1 active regulator and and use of the compounds in the manufacture of a drug for treating a disease regulated by ASK1. Further provided are a pharmaceutical composition and a method of treating a disease regulated by ASK1 comprising administering the compounds or pharmaceutical composition thereof.
COMPOUNDS AND COMPOSITIONS AS PDGFR KINASE INHIBITORS
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, (2013/03/28)
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase