369-34-6Relevant articles and documents
Method for pipeline continuous fluorination with fluorine salt as fluorine source
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Paragraph 0056-0061; 0094-0096, (2021/10/27)
The method comprises the following steps: dissolving a fluorine salt in an aqueous polar aprotic solvent as reaction liquid A, dissolving an aryl (heterocyclic) chloride in a polar aprotic solvent as reaction liquid B, and reacting a polar aprotic solvent in the reaction liquid A with a polar aprotic solvent of the reaction liquid B. The reaction medium consisting of the preheated reaction liquid A and the preheated reaction liquid B enters the reaction coil for a fluorination reaction, and the resulting product from the reaction coil is subjected to post-treatment to obtain the product. The method has the characteristics of no need of adding a phase transfer catalyst, continuous production, low production cost and the like.
Method for synthesizing 3-fluoro-4-(4-morpholinyl)aniline by using micro-channel reactor
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Paragraph 0027; 008-0059; 0067; 0075-0077; 0087, (2017/08/27)
The invention provides a method for synthesizing 3-fluoro-4-(4-morpholinyl)aniline by using a micro-channel reactor. The micro-channel reactor comprises a preheating module group composed of one or more parallely-connected preheating modules and a reactio
Copper-catalyzed hydrodefluorination of fluoroarenes by copper hydride intermediates
Lv, Hongbin,Cai, Yuan-Bo,Zhang, Jun-Long
supporting information, p. 3203 - 3207 (2013/04/23)
Breaking bad: Efficient copper-catalyzed C-F bond activation has been achieved by replacing fluorine with hydrogen. A copper hydride is proposed as the active intermediate, which proceeds through a nucleophilic attack on the fluorocarbon, as determined by experimental and theoretical results (see structure; C gray, H white, Cu light red, F light blue; distances in ?).