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37013-86-8

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37013-86-8 Usage

General Description

"1H-Pyrrole-2-carboxylic acid, 4-acetyl-3-ethyl-5-methyl-, ethyl ester" is a chemical compound that belongs to the class of pyrrole derivatives. It is a derivative of pyrrole carboxylic acid with an ethyl ester group attached to the carboxylic acid functionality. Additionally, it contains an acetyl group at position 4 and ethyl and methyl groups at positions 3 and 5, respectively. 1H-Pyrrole-2-carboxylic acid, 4-acetyl-3-ethyl-5-methyl-, ethyl ester may have potential applications in the field of organic synthesis and medicinal chemistry due to its unique structural features. However, further research and studies are needed to fully understand its properties and potential uses.

Check Digit Verification of cas no

The CAS Registry Mumber 37013-86-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,0,1 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 37013-86:
(7*3)+(6*7)+(5*0)+(4*1)+(3*3)+(2*8)+(1*6)=98
98 % 10 = 8
So 37013-86-8 is a valid CAS Registry Number.

37013-86-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4-acetyl-3-ethyl-5-methyl-1H-pyrrole-2-carboxylate

1.2 Other means of identification

Product number -
Other names 4-Acetyl-2-ethoxycarbonyl-3-ethyl-5-methylpyrrol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:37013-86-8 SDS

37013-86-8Relevant articles and documents

Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy

Bian, Yuanyuan,Chen, Yadong,Hong, Qianqian,Jiang, Fei,Kong, Bo,Li, Hongmei,Lu, Tao,Ma, Yu,Ran, Ting,Tang, Weifang,Wang, Cong,Yang, Na,Zhang, Zhimin,Zheng, Wan,Zhu, Jiapeng,Zhu, Zhaohong

, (2021/11/03)

As epigenetic readers, bromodomain and extra-terminal domain (BET) family proteins bind to acetylated-lysine residues in histones and recruit protein complexes to promote transcription initiation and elongation. Inhibition of BET bromodomains by small molecule inhibitors has emerged as a promising therapeutic strategy for cancer. Herein, we describe our efforts toward the discovery of a novel series of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as BET inhibitors. Intensive structural modifications led to the identification of compound 35f as the most active inhibitor of BET BRD4 with selectivity against BET family proteins. Further biological studies revealed that compound 35f can arrest the cell cycle in G0/G1 phase and induce apoptosis via decreasing the expression of c-Myc and other proteins related to cell cycle and apoptosis. More importantly, compound 35f showed favorable pharmacokinetic properties and antitumor efficacy in MV4-11 mouse xenograft model with acceptable tolerability. These results indicated that BET inhibitors could be potentially used to treat hematologic malignancies and some solid tumors.

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