371157-14-1Relevant articles and documents
Oxidize Amines to Nitrile Oxides: One Type of Amine Oxidation and Its Application to Directly Construct Isoxazoles and Isoxazolines
Zhang, Xiao-Wei,He, Xiao-Lin,Yan, Nan,Zheng, Hong-Xing,Hu, Xiang-Guo
, p. 15726 - 15735 (2020/11/30)
A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described. The unprecedented strategy of the oxidation of an amine directly to a nitrile oxide was used in this cyclization process. This reaction is highly efficient, regiospecific, operationally simple, mild, and tolerant of a variety of functional groups. Control experiments support a nitrile oxide intermediate mechanism for this novel class of oxidative cyclization reactions. Moreover, synthetic applications toward bioactive molecular skeletons and the late-stage modification of drugs were realized.
Solid-phase synthesis of isoxazoles using vinyl ethers as chameleon catches
Barrett, Anthony G. M.,Procopiou, Panayiotis A.,Voigtmann, Ulrike
, p. 3165 - 3168 (2007/10/03)
(figure presented) Regioselective 1,3-dipolar cycloadditions of supported vinyl ethers R1C(=CH2)O-CH2-polymer, prepared by the Tebbe olefination of R1CO2-CH2-polymer with ethyl cyanoformate
