3742-91-4

Basic information

• Product Name: benzyl piperidine-1-carboxylate
• CAS NO: 3742-91-4
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.2796
• Mol File: 3742-91-4.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 334.5°C at 760 mmHg
• Flash Point: 156.1°C
• Density: 1.119g/cm³
• Vapor Pressure: 0.000127mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: benzyl piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl piperidine-1-carboxylate(3742-91-4)
• EPA Substance Registry System: benzyl piperidine-1-carboxylate(3742-91-4)

Safety Data

• Hazardous Substances Data: 3742-91-4(Hazardous Substances Data)

Usage

General Description

Benzyl piperidine-1-carboxylate is a chemical compound consisting of a piperidine ring attached to a carboxylate group and a benzene ring. It is commonly used in organic synthesis and medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds. Benzyl piperidine-1-carboxylate is also known for its potential in the treatment of neurological disorders and as a precursor in the production of psychoactive substances. Due to its versatile nature and potential applications, this chemical compound is of interest to researchers and scientists in the pharmaceutical and chemical industries.

Upstream product

• 110-89-4 piperidine 
• 99464-81-0 benzyl (1-chloroethyl) carbonate 
• 74058-68-7 3-benzyloxycarbonyl-1,3-thiazolidine-2-thione 
• 100-51-6 benzyl alcohol 
• 591-87-7 Allyl acetate 
• 166953-64-6 benzyl 4-bromo-1-piperidinecarboxylate 
• 1417816-42-2 benzyl 4-pyridyl carbonate 
• 1397584-67-6 1-benzyl 3-methyl pyrazolidine-1,3-dicarboxylate 
• 2508-29-4 5-hydroxypentylamine 
• 501-53-1 benzyl chloroformate 
• 87905-98-4 5-<(benzyloxycarbonyl)amino>pentanol 
• 201230-82-2 carbon monoxide 
• 511244-40-9 N-benzyloxycarbonyl-5,7-dinitroindoline 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 

Downstream Products

• 66893-75-2 2-methoxypiperidine-1-carboxylic acid benzyl ester 
• 69622-67-9 benzyl 2-hydroxypiperidine-1-carboxylate 
• 1186400-96-3 Benzyl 4-(2-(4-methoxyphenylthio)ethylcarbamoyl)piperazine-1-carboxylate 
• 86827-08-9 benzyl 3-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate 
• 711002-74-3 (RS)-benzyl 3-aminopiperidine-1-carboxylate 
• 885069-22-7 3-cyano-piperidine-1-carboxylic acid benzyl ester 
• 174621-92-2 benzyl 3-acetoxypiperidine-1-carboxyate 
• 1010732-19-0 2,3,4-triacetoxy-piperidine-1-carboxylic acid benzyl ester 
• 799805-78-0 6-methoxy-3,6-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Photoredox catalysis on unactivated substrates with strongly reducing iridium photosensitizers

Photoredox catalysis has emerged as a powerful strategy in synthetic organic chemistry, but substrates that are difficult to reduce either require complex reaction conditions or are not amenable at all to photoredox transformations. In this work, we show that strong bis-cyclometalated iridium photoreductants with electron-rich β-diketiminate (NacNac) ancillary ligands enable high-yielding photoredox transformations of challenging substrates with very simple reaction conditions that require only a single sacrificial reagent. Using blue or green visible-light activation we demonstrate a variety of reactions, which include hydrodehalogenation, cyclization, intramolecular radical addition, and prenylationviaradical-mediated pathways, with optimized conditions that only require the photocatalyst and a sacrificial reductant/hydrogen atom donor. Many of these reactions involve organobromide and organochloride substrates which in the past have had limited utility in photoredox catalysis. This work paves the way for the continued expansion of the substrate scope in photoredox catalysis.

Cobalt-Catalyzed C(sp2)-C(sp3) Suzuki-Miyaura Cross Coupling

A cobalt-catalyzed method for the C(sp2)-C(sp3) Suzuki-Miyaura cross coupling of aryl boronic esters and alkyl bromides is described. Cobalt-ligand combinations were assayed with high-throughput experimentation, and cobalt(II) sources with trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCyDA, L1) produced optimal yield and selectivity. The scope of this transformation encompassed steric and electronic diversity on the aryl boronate nucleophile as well as various levels of branching and synthetically valuable functionality on the electrophile. Radical trap experiments support the formation of electrophile-derived radicals during catalysis.

A Simple, efficient, Catalyst-Free and Solvent-Less Microwave-Assisted process for N-Cbz Protection of Several amines

A simple, green and chemo-selective method for the N-benzyloxycarbonylation of amines, β-amino alcohols, α-amino esters and sulfonamides has been developed under microwave irradiation. Good to excellent yields of the N-benzyloxy-carbamates compounds were obtained in short times without any side products.