37527-66-5

Basic information

• Product Name: 3 4-DIMETHOXYPHENYL ISOCYANATE 98
• Synonyms: 3 4-DIMETHOXYPHENYL ISOCYANATE 98;4-isocyanato-1,2-dimethoxybenzene(SALTDATA: FREE);3,4-DiMethoxyphenyl isocyanate 98%;Benzene,4-isocyanato-1,2-dimethoxy-
• CAS NO: 37527-66-5
• Molecular Formula: C₉H₉NO₃
• Molecular Weight: 179.174
• Product Categories: Isocyanates;Nitrogen Compounds;Organic Building Blocks
• Mol File: 37527-66-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 261 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.204 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00703mmHg at 25°C
• Refractive Index: n20/D 1.558(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3 4-DIMETHOXYPHENYL ISOCYANATE 98(CAS DataBase Reference)
• NIST Chemistry Reference: 3 4-DIMETHOXYPHENYL ISOCYANATE 98(37527-66-5)
• EPA Substance Registry System: 3 4-DIMETHOXYPHENYL ISOCYANATE 98(37527-66-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 23-26-36
• RIDADR: UN 2206 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 37527-66-5(Hazardous Substances Data)

Usage

General Description

3,4-Dimethoxyphenyl isocyanate, an aryl isocyanate, is also known as 4-isocyanato-1,2-dimethoxybenzene.

InChI:InChI=1/C9H9NO3/c1-12-8-4-3-7(10-6-11)5-9(8)13-2/h3-5H,1-2H3

Upstream product

• 6315-89-5 3,4-dimethoxyaniline 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 93-07-2 Veratric acid 
• 40926-90-7 3,4-dimethoxybenzoyl azide 
• 75-44-5 phosgene 

Downstream Products

• 106107-52-2 methyl (3,4-dimethoxyphenyl)carbamate 
• 65141-27-7 N-(3,4-dimethoxyphenyl)-O-phenyl carbamate 
• 1119859-72-1 3-amino-N-(3,4-dimethoxyphenyl)-1H-indazole-1-carboxamide 
• 1373876-06-2 3-(3,4-dimethoxyphenyl)-1,1-bis(2-hydroxyethyl)urea 
• 890579-74-5 C₁₇H₁₈N₂O₅ 
• 1203719-50-9 3-[3-(3,4-dimethoxyphenyl)ureidomethyl]benzoic acid methyl ester 
• 1236291-32-9 1-(3,4-dimethoxyphenyl)-3-(2-oxo-2,3-dihydro-1H-indol-6-yl)urea 
• 1310550-07-2 C₁₈H₁₆FN₃O₃ 
• 1362623-75-3 C₂₀H₂₀N₂O₃ 
• 1362623-79-7 C₁₇H₂₀N₂O₃ 
• 1362623-71-9 C₂₂H₂₂N₂O₃ 
• 1362623-83-3 C₁₇H₂₀N₂O₃ 
• 1394293-76-5 C₂₀H₂₂N₄O₆S 
• 1447648-74-9 1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3,4-dimethoxyphenyl)urea 

Relevant articles and documents

Design, synthesis, and biological evaluation of tetrahydroisoquinoline-based diaryl urea derivatives for suppressing VEGFR-2 signaling

A novel structural series of tetrahydroisoquinoline-based compounds that incorporate the diaryl urea moiety was designed, synthesized, and biologically evaluated as suppressors of VEFGR-2 signaling. As a consequence, compounds 9k and 9s exhibited comparable or superior cytotoxic activity to that of gefitinib against the tested three cell lines, including A549, MCF-7, and PC-3. Importantly, both of them downregulated the expression of VEGFR-2, and inhibited VEGFR-2 phosphorylation at the concentration of 0.5 or 1.0 μmol/l. Besides, they suppressed human umbilical vein endothelial cell tube formation at the concentration of 4.0 μmol/l. Considering their capability of down-regulating VEGFR-2 expression and inhibiting VEGFR-2 phosphorylation, 9k and 9s may serve as suppressors of angiogenesis for further investigation.

Copper-catalyzed N[sbnd]H/S[sbnd]H functionalization: A strategy for the synthesis of benzothiadiazine derivatives

A copper-mediated N[sbnd]S bond-forming reaction via N[sbnd]H/S[sbnd]H activation is described. This reaction occurs under mild conditions with high efficiency, step economy, and tolerates a wide variety of functional groups, providing an efficient means of accessing biologically important 1,2,4-benzothiadiazin-3(4H)-ones.

Dipeptidyl peptidase inhibitors for the preparation of iodo, chloro, iodo intermediate and method

The invention provides an iodination preparation method for a dipeptidyl peptidase inhibitor, chlorination and iodination intermediates of the dipeptidyl peptidase inhibitor and preparation methods for the intermediates. According to the invention, an intermediate chlorinated compound is subjected to iodination in an organic solvent, and then a compound represented by a formula I and a salt thereof are prepared from an iodinated compound and used as the dipeptidyl peptidase inhibitor, wherein in the formula 1 descried in the invention, R1 is selected from an aryl group, a heteroaryl group and an alkyl group, or from an aryl group, a heteroaryl group and an alkyl group substituted by an alkyl or alkoxy group whose substituent groupp has a carbon atom number of C1 to C8, and X is an alkylene group with a carbon atom number of C1 to C8. Compared with conventional methods which prepare the compound represented by the formula I from brominated compounds, the method provided by the invention has the advantages of a substantial increase in yield and no need for column chromatographic purification, thereby facilitating industrial synthesis.