37554-70-4

Basic information

• Product Name: 2-chloro-5-fluoro-4-methoxypyrimidine
• Synonyms: 2-chloro-5-fluoro-4-methoxypyrimidine;2-Chloro-5-fluoro-4-methoxy-1,3-diazine
• CAS NO: 37554-70-4
• Molecular Formula: C₅H₄ClFN₂O
• Molecular Weight: 163
• EINECS: 604-604-1
• Mol File: 37554-70-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 280.9±20.0 °C(Predicted)
• Appearance: /
• Density: 1.400±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.05±0.29(Predicted)
• CAS DataBase Reference: 2-chloro-5-fluoro-4-methoxypyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-fluoro-4-methoxypyrimidine(37554-70-4)
• EPA Substance Registry System: 2-chloro-5-fluoro-4-methoxypyrimidine(37554-70-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 37554-70-4(Hazardous Substances Data)

Usage

General Description

2-chloro-5-fluoro-4-methoxypyrimidine is a chemical compound with the molecular formula C5H5ClFN2O. It is a pyrimidine derivative that contains chlorine, fluorine, and a methoxy group. 2-chloro-5-fluoro-4-methoxypyrimidine is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It can undergo various chemical reactions, including nucleophilic substitution and cross-coupling reactions, to produce different derivatives with potentially useful properties. Due to its versatile reactivity and functional groups, 2-chloro-5-fluoro-4-methoxypyrimidine is a valuable building block in organic synthesis and chemical research.

Upstream product

• 67-56-1 methanol 
• 2927-71-1 2,4-dichloro-5-fluoropyrimidine 
• 124-41-4 sodium methylate 

Downstream Products

• 1454303-02-6 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-oxazolo [5,4-c]pyridin-4-one 
• 1312535-38-8 5-fluoro-4-methoxy-N-[3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrimidin-2-amine 
• 1401349-58-3 N-tert-butyl-5-(3-(4-cyclopropyl-5-fluoropyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine 
• 1401349-57-2 N-tert-butyl-5-(3-(5-fluoro-4-methoxypyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine 
• 1382782-95-7 5-(5-fluoro-4-methoxy-pyrimidin-2-yl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one 
• 1365748-94-2 (5-fluoro-4-methoxypyrimidin-2-yl)phenylamine 

Relevant articles and documents

Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety

Herein we describe structure-activity relationship (SAR) and metabolite identification (Met-ID) studies that provided insight into the origin of time-dependent inhibition (TDI) of cytochrome P450 3A4 (CYP3A4) by compound 1. Collectively, these efforts revealed that bioactivation of the fluoropyrimidine moiety of 1 led to reactive metabolite formation via oxidative defluorination and was responsible for the observed TDI. We discovered that substitution at both the 4- and 6-positions of the 5-fluoropyrimidine of 1 was necessary to ameliorate this TDI as exemplified by compound 19.

Facile and regioselective synthesis of novel 2,4-disubstituted-5- fluoropyrimidines as potential kinase inhibitors

2,4-Disubstituted-5-fluoropyrimidine is a biologically active molecular core seen in various anticancer agents such as 5-fluorouracil (5-FU). As part of a programme aimed at discovering kinase inhibitors, routes to two series of novel compounds (5-fluorop

IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).