37885-41-9

Basic information

• Product Name: 2',4'-DICHLOROPROPIOPHENONE
• Synonyms: 1-(2,4-DICHLOROPHENYL)-1-PROPANONE;2',4'-DICHLOROPROPIOPHENONE;2,4-DICHLOROPROPIOPHENONE;1-Propanone, 1-(2,4-dichlorophenyl)-;1-(2,4-DICHLOROPHENYL)-1-PROPANONE 95%;1-(2,4-dichlorophenyl)propan-1-one;1-(2,4-Dichlorophenyl)-1-propanone,97%;1-(2,4-Dichlorophenyl)-1-propanone,95%
• CAS NO: 37885-41-9
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.07
• EINECS: 253-700-5
• Product Categories: Aromatic Propiophenones (substituted);Adehydes, Acetals & Ketones;Chlorine Compounds
• Mol File: 37885-41-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 121-123°C 7mm
• Flash Point: >110°C
• Appearance: Clear slightly yellow liquid
• Density: 1,287 g/cm3
• Refractive Index: 1.551-1.553
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: Slightly soluble in water
• BRN: 2248270
• CAS DataBase Reference: 2',4'-DICHLOROPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-DICHLOROPROPIOPHENONE(37885-41-9)
• EPA Substance Registry System: 2',4'-DICHLOROPROPIOPHENONE(37885-41-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 37885-41-9(Hazardous Substances Data)

Usage

Chemical Properties

Clear slightly yellow liquid

Uses

2',4'-Dichloropropiophenone is used in the synthesis of (S)-3-chloro-1-(4-chlorophenyl)-1-propanol.

InChI:InChI=1/C9H8Cl2O/c1-2-9(12)7-4-3-6(10)5-8(7)11/h3-5H,2H2,1H3

Upstream product

• 74-96-4 ethyl bromide 
• 6574-98-7 2,4-dichlorobenzylnitrile 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 53066-02-7 1-(2,4-dichlorophenyl)propan-1-ol 
• 79-03-8 propionyl chloride 
• 541-73-1 1,3-Dichlorobenzene 

Downstream Products

• 1073106-05-4 (S)-1-(2',4'-dichlorophenyl)propan-1-ol 
• 1034980-52-3 C₁₉H₁₄Cl₄N₂O₂ 
• 1034980-54-5 1,5-bis(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid 
• 1609483-07-9 ethyl 5-(2,4-dichlorophenyl)-4-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazole-3-carboxylate 
• 1609483-25-1 ethyl 5-(2,4-dichlorophenyl)-1-(4-(2,4-dichlorophenyl)-5-methylthiazol-2-yl)-4-methyl-1H-pyrazole-3-carboxylate 
• 1609483-24-0 ethyl 1-(4-(4-chlorophenyl)-5-methylthiazol-2-yl)-5-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxylate 
• 1141405-05-1 1-(2,4-dichlorophenyl)propan-1-amine 
• 1034980-50-1 ethyl 4-(2,4-dichlorophenyl)-3-methyl-2,4-dioxobutanoate 

Relevant articles and documents

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Itraconazole has been found to possess potent antiangiogenic activity, exhibiting promising antitumor activity in several human clinical studies. The wider use of itraconazole in the treatment of cancer, however, has been limited by its potent inhibition of the drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4). In an effort to eliminate the CYP3A4 inhibition while retaining its antiangiogenic activity, we designed and synthesized a series of derivatives in which the 1,2,4-triazole ring is replaced with various azoles and nonazoles. Among these analogues, 15n with tetrazole in place of 1,2,4-triazole exhibited optimal inhibition of human umbilical vein endothelial cell proliferation with an IC50 of 73 nM without a significant effect on CYP3A4 (EC50 > 20 μM). Similar to itraconazole, 15n induced Niemann-Pick C phenotype (NPC phenotype) and blocked AMPK/mechanistic target of rapamycin signaling. These results suggest that 15n is a promising angiogenesis inhibitor that can be used in combination with most other known anticancer drugs.

Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease

A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's disease and other related tauopathies.