38064-90-3

Basic information

• Product Name: 2,4-DIMETHOXYTOLUENE
• Synonyms: 2,4-DIMETHOXYTOLUENE;2,4-Dimethoxy-1-methylbenzene;Benzene, 1,3-dimethoxy-4-methyl;Benzene, 2,4-dimethoxy-1-methyl-
• CAS NO: 38064-90-3
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Anisoles, Alkyloxy Compounds & Phenylacetates;D;Stains and Dyes;Stains&Dyes, A to
• Mol File: 38064-90-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 110-120 °C30 mm Hg(lit.)
• Flash Point: 199 °F
• Appearance: /
• Density: 1.036 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.271mmHg at 25°C
• Refractive Index: n20/D 1.524(lit.)
• Storage Temp.: room temp
• CAS DataBase Reference: 2,4-DIMETHOXYTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIMETHOXYTOLUENE(38064-90-3)
• EPA Substance Registry System: 2,4-DIMETHOXYTOLUENE(38064-90-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 38064-90-3(Hazardous Substances Data)

Usage

General Description

2,4-dimethoxytoluene is a chemical compound with the molecular formula C9H12O2. It is a colorless liquid with a strong odor and is commonly used as a solvent in various industrial and commercial applications. It is also used in the production of chemicals, pharmaceuticals, and other products. 2,4-dimethoxytoluene is flammable and may be harmful if inhaled or ingested, and can cause skin and eye irritation. It is important to handle and store this chemical compound with proper safety measures to prevent any potential hazards.

InChI:InChI=1/C9H12O2/c1-7-4-5-8(10-2)6-9(7)11-3/h4-6H,1-3H3

Upstream product

• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 
• 496-73-1 4-methyl resorcinol 
• 77-78-1 dimethyl sulfate 
• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 616-38-6 carbonic acid dimethyl ester 
• 82477-57-4 2-chloro-4,6-dimethoxy-3-methylaniline 
• 13362-33-9 2-methyl-1,4-benzoquinone 4-oxime 
• 7664-93-9 sulfuric acid 
• 23438-23-5 4-hydroxy-4-methyl-cyclohexa-2,5-dienone 
• 68-12-2 N,N-dimethyl-formamide 
• 917-54-4 methyllithium 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 82477-58-5 2-chloro-4,6-dimethoxytoluene 
• 67-56-1 methanol 

Downstream Products

• 496-73-1 4-methyl resorcinol 
• 923556-77-8 C₁₆H₂₅NO₃ 
• 1402588-86-6 C₅₀H₇₉NO₁₂Si₂ 
• 1402588-85-5 C₅₈H₈₇NO₁₃Si₂ 
• 1402588-84-4 C₅₁H₈₃NO₁₂Si₂ 
• 1402589-26-7 C₅₁H₈₃NO₁₂Si₂ 
• 1402588-83-3 C₄₁H₆₃NO₉Si₂ 
• 1402588-81-1 C₄₂H₆₇NO₉Si₂ 
• 1402588-80-0 C₅₀H₇₅NO₁₀Si₂ 
• 864514-30-7 (2S,4R,6R)-6-{(2S,3R)-3-[(R)-6,8-Bis-(4-methoxy-benzyloxy)-5-methyl-1-oxo-isochroman-3-yl]-2-hydroxy-butyl}-4-hydroxy-5,5-dimethyl-tetrahydro-pyran-2-carboxylic acid amide 

Relevant articles and documents

Pd-Catalyzed ipso, meta-Dimethylation of ortho-Substituted Iodoarenes via a Base-Controlled C-H Activation Cascade with Dimethyl Carbonate as the Methyl Source

A methyl group can have a profound impact on the pharmacological properties of organic molecules. Hence, developing methylation methods and methylating reagents is essential in medicinal chemistry. We report a palladium-catalyzed dimethylation reaction of ortho-substituted iodoarenes using dimethyl carbonate as a methyl source. In the presence of K2CO3 as a base, iodoarenes are dimethylated at the ipso- and meta-positions of the iodo group, which represents a novel strategy for meta-C-H methylation. With KOAc as the base, subsequent oxidative C(sp3)-H/C(sp3)-H coupling occurs; in this case, the overall transformation achieves triple C-H activation to form three new C-C bonds. These reactions allow expedient access to 2,6-dimethylated phenols, 2,3-dihydrobenzofurans, and indanes, which are ubiquitous structural motifs and essential synthetic intermediates of biologically and pharmacologically active compounds.

A solvent-controlled highly efficient Pd-C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes via a novel 'acetal pathway'

Pd-C catalyzed hydrogenolysis of benzaldehydes to methylbenzenes has been described to proceed via a 'benzenemethanol pathway'. In this article, a novel 'acetal pathway' was first revealed by a systematic study when lower alcohols were used as solvents and a solvent-controlled highly efficient procedure was established.

The Synthesis of Mycophenolic Acid from 2,4-Dihydroxybenzoic Acid

Mycophenolic acid (1) has been synthesized from 2,4-dihydroxybenzoic acid by regioselective introduction of the three required carbon substituents.A key transformation in this sequence is the introduction of the methyl substituent at position 5 by a rapid, uncatalyzed replacement of the bromide in 8 at low temperature by methyllithium.The scope and mechanism of this methylation reaction are examined.