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38235-71-1

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38235-71-1 Usage

General Description

3-Hydrazinobenzoic acid is a chemical compound with the molecular formula C7H8N2O2. It is a derivative of benzoic acid, containing a hydrazine functional group. 3-HYDRAZINOBENZOIC ACID is commonly used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and dyes. It has also been studied for its potential anticancer and antitubercular activities. 3-Hydrazinobenzoic acid has been found to inhibit the growth of cancer cells and exhibit promising antimicrobial properties. Additionally, it has been explored for its use in the preparation of corrosion inhibitors. Overall, this compound has garnered attention for its diverse range of potential applications in the fields of medicine, agriculture, and materials science.

Check Digit Verification of cas no

The CAS Registry Mumber 38235-71-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,2,3 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 38235-71:
(7*3)+(6*8)+(5*2)+(4*3)+(3*5)+(2*7)+(1*1)=121
121 % 10 = 1
So 38235-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O2/c8-9-6-3-1-2-5(4-6)7(10)11/h1-4,9H,8H2,(H,10,11)

38235-71-1 Well-known Company Product Price

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  • Alfa Aesar

  • (B21462)  3-Hydrazinobenzoic acid, 99%   

  • 38235-71-1

  • 10g

  • 557.0CNY

  • Detail
  • Alfa Aesar

  • (B21462)  3-Hydrazinobenzoic acid, 99%   

  • 38235-71-1

  • 50g

  • 2103.0CNY

  • Detail
  • Alfa Aesar

  • (B21462)  3-Hydrazinobenzoic acid, 99%   

  • 38235-71-1

  • 250g

  • 8882.0CNY

  • Detail

38235-71-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-HYDRAZINOBENZOIC ACID

1.2 Other means of identification

Product number -
Other names Benzoic acid, 3-hydrazino-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38235-71-1 SDS

38235-71-1Relevant articles and documents

Discovery of novel inhibitors of human phosphoglycerate dehydrogenase by activity-directed combinatorial chemical synthesis strategy

Gou, Kun,Luo, Youfu,Luo, Yuan,Sun, Qingxiang,Tan, Yuping,Tao, Lei,Zhao, Yinglan,Zhou, Xia,Zhou, Yue,Zuo, Zeping

, (2021/07/26)

Serine, the source of the one-carbon units essential for de novo purine and deoxythymidine synthesis plays a crucial role in the growth of cancer cells. Phosphoglycerate dehydrogenase (PHGDH) which catalyzes the first, rate-limiting step in de novo serine biosynthesis has become a promising target for the cancer treatment. Here we identified H-G6 as a potential PHGDH inhibitor from the screening of an in-house small molecule library based on the enzymatic assay. We adopted activity-directed combinatorial chemical synthesis strategy to optimize this hit compound. Compound b36 was found to be the noncompetitive and the most promising one with IC50 values of 5.96 ± 0.61 μM against PHGDH. Compound b36 inhibited the proliferation of human breast cancer and ovarian cancer cells, reduced intracellular serine synthesis, damaged DNA synthesis, and induced cell cycle arrest. Collectively, our results suggest that b36 is a novel PHGDH inhibitor, which could be a promising modulator to reprogram the serine synthesis pathway and might be a potential anticancer lead worth further exploration.

Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor

Bowers, Erin M.,Yan, Gai,Mukherjee, Chandrani,Orry, Andrew,Wang, Ling,Holbert, Marc A.,Crump, Nicholas T.,Hazzalin, Catherine A.,Liszczak, Glen,Yuan, Hua,Larocca, Cecilia,Saldanha, S. Adrian,Abagyan, Ruben,Sun, Yan,Meyers, David J.,Marmorstein, Ronen,Mahadevan, Louis C.,Alani, Rhoda M.,Cole, Philip A.

scheme or table, p. 471 - 482 (2011/08/06)

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported, a potent, selective, and readily available active-sitedirected small molecule inhibitor is not yet known. Here we use a structure-based, in silico screening approach to identify a commercially available pyrazolone- containing small molecule p300 HAT inhibitor, C646. C646 is a competitive p300 inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases. Studies on site-directed p300 HAT mutants and synthetic modifications of C646 confirm the importance of predicted interactions in conferring potency. Inhibition of histone acetylation and cell growth by C646 in cells validate its utility as a pharmacologic probe and suggest that p300/CBP HAT is a worthy anticancer target.

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