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38256-25-6

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38256-25-6 Usage

General Description

Dimethyl trans-2-oxoglutaconate is a chemical compound that belongs to the class of organic compounds known as glutamic acid and derivatives. It is a derivative of glutaric acid and is commonly used in the synthesis of organic compounds. This chemical has potential medicinal properties and has shown to be effective in suppressing the production of pro-inflammatory cytokines in activated macrophages. It is also utilized in the production of certain pharmaceuticals and is used in research and medical laboratories as a building block for the synthesis of various compounds. Additionally, it has potential applications in the field of agriculture and may have use as an intermediate in the production of crop protection chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 38256-25-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,2,5 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 38256-25:
(7*3)+(6*8)+(5*2)+(4*5)+(3*6)+(2*2)+(1*5)=126
126 % 10 = 6
So 38256-25-6 is a valid CAS Registry Number.

38256-25-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-4-oxopent-2-enedioic acid dimethyl ester

1.2 Other means of identification

Product number -
Other names DOG

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38256-25-6 SDS

38256-25-6Relevant articles and documents

Selective Oxidations with Activated Carbon: Applications to Substrates containing Acidic Allylic Methine and Methylene Groups

Ananda, G. D. Sriyani,Cremins, Peter J.,Stoodley, Richard J.

, p. 882 - 883 (1987)

Butenoates substituted at the γ-position with an acidifying group, e.g., COR, CO2R, SO2R, and PO(OR)2, undergo a regioselective oxidation (in which a methine group is converted into a carbinol function and a methylene group into a keto moiety) in the presence of activated carbon.

TREATMENT OF DISORDERS ASSOCIATED WITH OXIDATIVE STRESS AND COMPOUNDS FOR SAME

-

, (2021/09/17)

The present invention relates to the treatment of disorders associated with oxidative stress including neuropathic pain and small synthetically derived compounds for treating such disorders.

Convergent Synthesis of Diverse Nitrogen Heterocycles via Rh(III)-Catalyzed C-H Conjugate Addition/Cyclization Reactions

Weinstein, Adam B.,Ellman, Jonathan A.

supporting information, p. 3294 - 3297 (2016/07/13)

The development of Rh(III)-catalyzed C-H conjugate addition/cyclization reactions that provide access to synthetically useful fused bi- and tricyclic nitrogen heterocycles is reported. A broad scope of C-H functionalization substrates and electrophilic olefin coupling partners is effective, and depending on the nature of the directing group, cyclic imide, amide, or heteroaromatic products are obtained. An efficient synthesis of a pyrrolophenanthridine alkaloid natural product, oxoassoanine, highlights the utility of this method.

Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport

Carrigan, Christina N.,Bartlett, Richard D.,Esslinger, C. Sean,Cybulski, Kimberly A.,Tongcharoensirikul, Pakamas,Bridges, Richard J.,Thompson, Charles M.

, p. 2260 - 2276 (2007/10/03)

The vesicular glutamate transport (VGLUT) system selectively mediates the uptake of L-glutamate into synaptic vesicles. Uptake is linked to an H+-ATPase that provides coupling among ATP hydrolysis, an electrochemical proton gradient, and glutamate transport. Substituted quinoline-2,4-dicarboxylic acids (QDCs), prepared by condensation of dimethyl ketoglutaconate (DKG) with substituted anilines and subsequent hydrolysis, were investigated as potential VGLUT inhibitors in synaptic vesicles. A brief panel of substituted QDCs was previously reported (Carrigan et al. Bioorg. Med. Chem. Lett. 1999, 9, 2607-2612)1 and showed that certain substituents led to more potent competitive inhibitors of VGLUT. Using these compounds as leads, an expanded series of QDC analogues were prepared either by condensation of DKG with novel anilines or via aryl-coupling (Suzuki or Heck) to dimethyl 6-bromoquinolinedicarboxylate. From the panel of almost 50 substituted QDCs tested as inhibitors of the VGLUT system, the 6-PhCH=CH-QDC (Ki = 167 μM), 6-PhCH2CH2-QDC (Ki = 143 μM), 6-(4′-phenylstyryl)-QDC (Ki = 64 μM), and 6-biphenyl-4-yl-QDC (Ki=41 μM) were found to be the most potent blockers. A preliminary assessment of the key elements needed for binding to the VGLUT protein based on the structure-activity relationships for the panel of substituted QDCs is discussed herein. The substituted QDCs represent the first synthetically derived VGLUT inhibitors and are promising templates for the development of selective transporter inhibitors.

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