3839-31-4

Basic information

• Product Name: Lithium, (dimethylphenylsilyl)-
• CAS NO: 3839-31-4
• Molecular Formula: C8H11LiSi
• Molecular Weight: 142.202
• Mol File: 3839-31-4.mol
• Article Data: 28

Chemical Properties

• CAS DataBase Reference: Lithium, (dimethylphenylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Lithium, (dimethylphenylsilyl)-(3839-31-4)
• EPA Substance Registry System: Lithium, (dimethylphenylsilyl)-(3839-31-4)

Safety Data

• Hazardous Substances Data: 3839-31-4(Hazardous Substances Data)

Usage

General Description

Lithium, (dimethylphenylsilyl)-, also known as lithium dimethylphenylsilane or Li(DMPS), is a lithium organometallic compound used as a reagent in organic synthesis. It is a powerful base and nucleophile, commonly used in the formation of carbon-carbon and carbon-heteroatom bonds. The compound is often utilized in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is known for its high reactivity and selectivity in various synthetic transformations, making it a valuable tool in organic chemistry. However, its extreme air and moisture sensitivity requires careful handling and storage.

Upstream product

• 1145-98-8 1,2-diphenyltetramethyldisilane 
• 768-33-2 phenyldimethylsilyl chloride 
• 185990-03-8 dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane 

Downstream Products

• 1130-17-2 1,1,1,2,2-pentamethyl-2-phenyldisilane 
• 18748-58-8 (diphenylmethoxy)(phenyl)dimethylsilane 
• 101751-24-0 (Z)-1-dimethylphenylsilyl-2-hexyl-1-hepten-4-ol 
• 104066-53-7 (E)-1-dimethylphenylsilyl-4-(2-tetrahidropyranyloxy)-1-butene 
• 104066-54-8 dimethyl(phenyl)(4-((tetrahydro-2H-pyran-2-yl)oxy)but-1-en-2-yl)silane 
• 98689-47-5 tetrahydropyranyl ether of (Z)-3,4-bis(dimethylphenylsilyl)-3-buten-1-ol 
• 98689-48-6 tetrahydropyranyl ether of (E)-3,4-bis(dimethylphenylsilyl)-3-buten-1-ol 
• 87436-97-3 C₉H₁₄MgSi 
• 80256-22-0 3-(dimethylphenylsilyl)-3-methyl-1-trimethylsilyloxycyclopentene 
• 118714-86-6 3-(dimethylphenylsilyl)-2-methyl-1-<(trimethylsilyl)oxy>cyclopentene 
• 107824-81-7 tert-Butyl-[2-tert-butylimino-1-(dimethyl-phenyl-silanyl)-vinyl]-trimethylsilanyl-amine 
• 107824-80-6 N,N'-Di-tert-butyl-N-(dimethyl-phenyl-silanyl)-N'-trimethylsilanyl-ethyne-1,2-diamine 
• 117917-66-5 C₂₂H₂₃⁽²⁾HO₂SSi 
• 117917-66-5 C₂₂H₂₃⁽²⁾HO₂SSi 

Relevant articles and documents

A Tandem Non-Aldol Aldol Mukaiyama Aldol Reaction

(Equation presented) A new one-pot tandem aldol process is described in which a secondary epoxy silyl ether is converted into the 1,5-bis-silyloxy-3- alkanone in good yield. Thus, treatment of the epoxy silyl ether 8 with TBSOTf and base affords the silyl

Tuning of α-Silyl Carbocation Reactivity into Enone Transposition: Application to the Synthesis of Peribysin D, E-Volkendousin, and E-Guggulsterone

A reliable method for enone transposition has been developed with the help of silyl group masking. Enantio-switching, substituent shuffling, and Z-selectivity are the highlights of the method. The developed method was applied for the first total synthesis of peribysin D along with its structural revision. Formal synthesis of E-guggulsterone and E-volkendousin was also claimed using a short sequence.

Organocatalyzed Diastereo- and Enantioselective Conjugate Addition of Nitroalkanes to β-Silylmethylene Malonates: Direct Access to Enantioenriched Organosilanes

Cinchona-alkaloid derived bifunctional thiourea catalyzed conjugate addition reaction of nitroalkanes to β-silylmethylene malonates is reported for direct access of densely functionalized enantioenriched organosilanes in good yields (up to 86 %) with exce