385380-74-5

Basic information

• Product Name: 1-(2-Fluoro-4-nitrophenyl)pyrrolidine
• Synonyms: 1-(2-Fluoro-4-nitrophenyl)pyrrolidine;3-Fluoro-4-(pyrrolidin-1-yl)nitrobenzene
• CAS NO: 385380-74-5
• Molecular Formula: C₁₀H₁₁FN₂O₂
• Molecular Weight: 210.207
• Mol File: 385380-74-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 345.1 °C at 760 mmHg
• Flash Point: 162.5 °C
• Appearance: /Solid
• Density: 1.313g/cm³
• Vapor Pressure: 6.32E-05mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-Fluoro-4-nitrophenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Fluoro-4-nitrophenyl)pyrrolidine(385380-74-5)
• EPA Substance Registry System: 1-(2-Fluoro-4-nitrophenyl)pyrrolidine(385380-74-5)

Safety Data

• Hazardous Substances Data: 385380-74-5(Hazardous Substances Data)

Usage

General Description

1-(2-Fluoro-4-nitrophenyl)pyrrolidine is an organic compound which features in various scientific and industrial applications. Its structure consists of a pyrrolidine ring, which is a five-membered ring with nitrogen as one of the atoms, bound to a 2-fluoro-4-nitrophenyl group. 1-(2-Fluoro-4-nitrophenyl)pyrrolidine is typically a white to off-white solid and, like many organofluorine compounds, it is relatively stable and has strong carbon-fluorine bonds. It is primarily utilized in chemical synthesis, acting as an intermediate in the production of more complex molecules. Not much is known about its potential hazards and environmental impact but like most chemicals, it should be handled with care.

InChI:InChI=1/C10H11FN2O2/c11-9-7-8(13(14)15)3-4-10(9)12-5-1-2-6-12/h3-4,7H,1-2,5-6H2

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 123-75-1 pyrrolidine 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 1542258-15-0 3-(3-fluoro-4-(pyrrolidin-1-yl)phenyl)-2,6-dimethylpyrimidine-4(3H)-one 
• 93246-54-9 3-fluoro-4-(pyrrolidin-1-yl)aniline 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS

The invention relates to the field of medicine, discloses new nitrogen heterocyclic derivatives, preparation method thereof and as medicament in particular as the treatment and prevention of treating tissue fibrosis of the medicament. The invention also discloses a pharmaceutically acceptable compound of the present invention comprise a pharmaceutical composition and methods for using the composition for the treatment of the human or animal tissue fibrosis of diseases, in particular for treating the human or animal renal interstitial fibrosis, glomerular sclerosis, hepatic fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, skin fibrosis, after the operation of adhering, benign prostate hypertrophy, bone-myocardial, scleroderma, multiple sclerosis, pancreas fibrosis, liver cirrhosis, myosarcoma, neurofibromatosis, interstitial pulmonary fibrosis, diabetic nephropathy, Alzheimer's disease or vascular fibrosis disease in use. (by machine translation)

NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.

Cu(I)-mediated deoxygenation of N-oxides to amines

A mild and highly efficient deoxygenation of variety of N-oxides using an inexpensive CuX, or a CuX-Zn or CuX-Al couple is described.