386213-32-7

Basic information

• Product Name: FMOC-LYS(MCA)-OH
• Synonyms: N-α-Fmoc-N-ω-7-methoxycoumarin-4-acetyl-L-Lys-OH;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-(7-METHOXYCOUMARIN-4-YL) ACETYL-L-LYSINE;N-ALPHA-FMOC-N-EPSILON-7-METHOXYCOUMARIN-4-ACETYL-L-LYSINE;FMOC-LYS(MCA)-OH;FMOC-LYSINE(MCA)-OH;(S)-2-(N-(((9H-fluoren-9-yl)methyl9H-fluoren-9-yl)methoxy)carbonyl)acetamido)-6-(7-methoxy-2-oxo-2H-chromen-4-ylamino)hexanoic acid;(S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-6-(2-(7-Methoxy-2-oxo-2H-chroMen-4-yl)acetaMido)hexanoic acid;N-α-Fmoc-N-ω-7-methoxycoumarin-4-acetyl-L-lysine
• CAS NO: 386213-32-7
• Molecular Formula: C33H32N2O8
• Molecular Weight: 584.62
• Product Categories: amino acids
• Mol File: 386213-32-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 885.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.309±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.87±0.21(Predicted)
• CAS DataBase Reference: FMOC-LYS(MCA)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-LYS(MCA)-OH(386213-32-7)
• EPA Substance Registry System: FMOC-LYS(MCA)-OH(386213-32-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 386213-32-7(Hazardous Substances Data)

Usage

General Description

FMOC-LYS(MCA)-OH is a chemical compound commonly used in peptide synthesis. It consists of the FMOC (Fluorenylmethyloxycarbonyl) protecting group, which is commonly used to protect the terminal amino group in the process of peptide synthesis. The LYS(MCA) portion of the compound refers to the amino acid lysine with an MCA (7-methoxycoumarin-4-yl) fluorescent moiety attached. This fluorescent tag is often used to label peptides in biochemical assays for detection and quantification. The OH at the end indicates that the compound has a free carboxylic acid group, enabling it to be used in peptide coupling reactions. Overall, FMOC-LYS(MCA)-OH is a versatile compound used in the synthesis and analysis of peptides in the field of biochemistry and molecular biology.

Upstream product

• 1101836-32-1 4-(benzotriazole-1-ylacetyl)-7-methoxycoumarin 
• 105047-45-8 Fmoc-Lys-OH 
• 940941-43-5 Nα-fluorenylmethyloxycarbonyl-L-lysine-tert-butyl ester 
• 62935-72-2 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid 

Downstream Products

• 1006709-29-0 C₇₉H₁₀₈BrN₁₁O₁₈S 
• 1217351-13-7 C₈₆H₁₂₆N₁₆O₃₈ 

Relevant articles and documents

Preparation method of N alpha- fluorenylmethoxycarbonyl-N Epsilon-7-methoxycoumarin-4-acetyl-lysine/ornithine

The invention relates to a preparation method of N alpha-fluorenylmethoxycarbonyl-N-Epsilon-7-methoxycoumarin-4-acetyl-lysine/ornithine and mainly aims to solve the problems that a current method is complicated in treatment, lower in yield and not environment-friendly. According to the technical scheme, the preparation method of N alpha-fluorenylmethoxycarbonyl-N-Epsilon-7-methoxycoumarin-4-acetyl-lysine/ornithine comprises steps as follows: N alpha-fluorenylmethoxycarbonyl-N Epsilon-7-methoxycoumarin-4-acetyl-lysine/ornithine tert-butyl ester is produced from N alpha-fluorenylmethoxycarbonyl-lysine/ornithine tert-butyl ester and 7-methoxycoumarin-4-acetic acid through condensation under catalysis of a condensing agent, tert-butyl ester is removed from N alpha-fluorenylmethoxycarbonyl-N Epsilon-7-methoxycoumarin-4-acetyl-lysine/ornithine tert-butyl ester by use of trifluoroacetic acid, and a product, namely, N alpha-fluorenylmethoxycarbonyl-N-Epsilon-7-methoxycoumarin-4-acetyl-lysine/ornithine is obtained. The product is mainly used as a fluorescent probe or a marker.