3866-16-8

Basic information

• Product Name: 3-Azidoanisole
• Synonyms: 1-Azido-3-methoxybenzene;3-Azidoanisole;3-Methoxyphenyl azide;1-Azido-3-methoxybenzene solution;3-Azidoanisole solution;3-Methoxyphenyl azide solution
• CAS NO: 3866-16-8
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 0
• Product Categories: Aromatic Azides;Azides;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 3866-16-8.mol
• Article Data: 85

Chemical Properties

• Flash Point: -33°C
• Appearance: /
• Storage Temp.: ?20°C
• BRN: 2090296
• CAS DataBase Reference: 3-Azidoanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azidoanisole(3866-16-8)
• EPA Substance Registry System: 3-Azidoanisole(3866-16-8)

Safety Data

• Hazard Codes: F,T
• Statements: 11-38-48/23/24/25
• Safety Statements: 16
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 3866-16-8(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 10365-98-7 3-methoxyphenylboronic acid 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 19183-05-2 3-methoxy-benzenediazonium; chloride 
• 2398-37-0 3-methoxyphenyl bromide 
• 15384-39-1 (3-methoxyphenyl)hydrazine 
• 555-03-3 3-nitroanisole 

Downstream Products

• 18615-47-9 N-(3-methoxy-phenylimino)-triphenyl-phosphorane 
• 325485-16-3 dimethyl 1-(3-methoxyphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate 
• 536-90-3 m-Anisidine 
• 237067-33-3 C₁₇H₁₄N₂O₂ 

Relevant articles and documents

Towards smart biocide-free anti-biofilm strategies: Click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria

A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 =

Immobilization of vitamin B1 on the magnetic dialdehyde starch as an efficient carbene-type support for the copper complexation and its catalytic activity examination

Since the starch biopolymer is an available and inexpensive matrix with modifiable functionality and stabilization capability for metal ions, in this report, we oxidized it to dialdehyde form for the further functionalization with vitamin B1 as a green σ-donor and π-acceptor carbene type ligand. Immobilization of vitamin B1 on this biopolymer was done through imine bond formation between NH2 groups of aminopyrimidine segment of vitamin B1 and aldehyde functional groups of starch oxide. Thiazolium heterocycle part in this biomolecule provided a carbene type precursor for the metal complexation. After the magnetization process by using of Fe3O4 nanoparticles that lead to quick and facile magnetic separation and metal catalyst recycling, copper ions immobilized on the magnetic support (5.9 wt% Cu, 0.93 mmol/g). The prepared copper N-heterocyclic carbene complex (Fe3O4@DAS@VB1@CuCl nanocomposite) was characterized by FT-IR, SEM, EDX, XRD, VSM, TGA and ICP-OES analysis and then its catalytic activity investigated in azidonation of arylboronic acids and also one-pot coupling reaction of the synthesized aryl azides with phenylacetylene. 1,4-Diaryl 1,2,3-triazoles were obtained in excellent yields (≥90%) at proper reaction times (30–200 min). The magnetic catalyst was recovered by a magnetic field and reused in azidation reaction up to 7 cycle.

Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors

Tranylcypromine (TCP)-based structural modifications lead to the discovery of new LSD1 inhibitors, of which compounds 26b and 29b effectively inhibit LSD1 with the IC50 values of 17 and 11 nM, respectively and also show good selectivity over MAO-B. Mechanistic studies showed that compound 29b concentration-dependently induced H3K4me1/2 accumulation in LSD1 overexpressed MGC-803 cells and also inhibited metastasis of MGC-803 cells. Collectively, both compounds could be promising lead compounds for further investigation.