38677-85-9

Basic information

• Product Name: FLUNIXIN MEGLUMINE
• Synonyms: Flunixin VETRANAL;FlunixinMeglumineBase;3-Pyridinecarboxylic acid, 2-2-methyl-3-(trifluoromethyl)phenylamino-;2-(2-Methyl-3-trifluoromethylanilino)nicotinic Acid;2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid;Sch 14714;2-[2-Methyl-3-(trifluoromethyl)phenylamino]nicotinic acid;FLUNIXINE MEGLUMINE SALT
• CAS NO: 38677-85-9
• Molecular Formula: C₁₄H₁₁F₃N₂O₂
• Molecular Weight: 296.25
• EINECS: 255-836-0
• Product Categories: Organics;Aromatics Compounds;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 38677-85-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 136.6-137.4 °C
• Boiling Point: 378.7 °C at 760 mmHg
• Flash Point: 182.8 °C
• Appearance: off-white/solid
• Density: 1.403 g/cm³
• Vapor Pressure: 2.08E-06mmHg at 25°C
• Refractive Index: 1.582
• Solubility: H2O: freely soluble
• PKA: 5.82(at 25℃)
• Stability: Stable. Incompatible with strong bases, strong oxidizing agents.
• CAS DataBase Reference: FLUNIXIN MEGLUMINE(CAS DataBase Reference)
• NIST Chemistry Reference: FLUNIXIN MEGLUMINE(38677-85-9)
• EPA Substance Registry System: FLUNIXIN MEGLUMINE(38677-85-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• RIDADR: UN2811 6.1/PG 3
• WGK Germany: 3
• RTECS: LZ4367000
• Hazardous Substances Data: 38677-85-9(Hazardous Substances Data)

Usage

Chemical Properties

Crystalline Solid

Definition

ChEBI: A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a 2-methyl-3-(trifluoromethyl)phenylamino group. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic properties; sed in veterinary medicine (usually as the meglumine salt) for treatment of horses, cattle and pigs.

General Description

Flunixin is classified under the group of non-steroidal anti-inflammatory drugs (NSAIDs).

InChI:InChI=1/C14H11F3N2O2/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12/h2-7H,1H3,(H,18,19)(H,20,21)

Upstream product

• 54396-42-8 ethyl 2-(2-methyl-3-trifluoromethylanilino)nicotinate 
• 1939-19-1 N-(3-(trifluoromethyl)phenyl)pivalamide 
• 54396-44-0 2-methyl-3-trifluoromethylaniline 
• 98-16-8 3-trifluoromethylaniline 
• 1452-94-4 ethyl 2-chloronicotinate 
• 150783-50-9 2-methyl-3-pivaloylaminobenzotrifluoride 
• 2942-59-8 2-chloronicotinic acid 
• 42461-84-7 flunixin Meglumine 

Downstream Products

• 75369-61-8 5-hydroxyflunixin 
• 42461-84-7 flunixin Meglumine 

Relevant articles and documents

Polymorphism in the Anti-inflammatory Drug Flunixin and Its Relationship with Clonixin

Crystallization of the nonsteroidal anti-inflammatory drug (NSAID) flunixin in acetone and in acetone-hexane produced two conformational polymorphs, as predicted by hydrogen-bond propensity analyses, which are similar to three of the polymorphs of the rel

Preparation method of flunixin meglumine

The invention discloses a preparation method of flunixin meglumine the preparation method, and the method specifically comprises the following steps: (1) adding 2-chloronicotinic acid and 2-methyl-3-trifluoromethyl aniline into a sodium hydroxide water solution for stirring, adding ethylene glycol as well as a phase transfer catalyst and p-toluenesulfonic acid and copper oxide, controlling the temperature and time, adjusting the pH value of the solution, stirring, standing, layering, stirring, filtering, washing filter cake, and drying to obtain flunixin; and (2) reacting the flunixin obtainedin the step (1) with N-methylglucosamine in isopropyl alcohol, and meanwhile, adding a filler; carrying out heating reflux, filtering, cooling, stirring and crystallizing, carrying out crystal suction filtration, and washing crystals with isopropanol to obtain the flunixin meglumine. The preparation method of the flunixin meglumine is convenient and simple in operation, the reflecting efficiencyis high, the reaction temperature is low, the reaction time is short, and the cost is low; moreover, the prepared flunixin meglumine is high in purity and high in yield.

Process for preparing flunixin and intermediates thereof

Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.