38791-92-3

Basic information

• Product Name: 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE
• Synonyms: 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE
• CAS NO: 38791-92-3
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 38791-92-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 64-67°C
• Boiling Point: 337.3°C at 760 mmHg
• Flash Point: 142.8°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 0.000106mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE(38791-92-3)
• EPA Substance Registry System: 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE(38791-92-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 38791-92-3(Hazardous Substances Data)

Usage

General Description

4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE is a chemical compound with the molecular formula C9H7NO2. It is a benzene derivative with a nitrile group and an epoxide moiety attached to it. 4-(2-OXIRANYLMETHOXY)BENZENECARBONITRILE is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various organic compounds. It can undergo various chemical reactions such as nucleophilic addition, substitution, and ring-opening reactions due to the presence of the epoxide group. The compound has potential applications in the development of new drugs and as a reagent in organic chemical reactions.

InChI:InChI=1/C10H9NO2/c11-5-8-1-3-9(4-2-8)12-6-10-7-13-10/h1-4,10H,6-7H2

Upstream product

• 767-00-0 4-cyanophenol 
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Downstream Products

• 227940-77-4 4-[(3-amino-2-hydroxypropyl)oxy]benzonitrile 
• 1254122-78-5 4-[2-hydroxy-3-(3-methyl-4-(p-tolyl)piperazin-1-yl)propoxy]benzonitrile 
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• 1454703-63-9 4-(2-hydroxy-3-(decylamino)propoxy)benzonitrile 
• 1454703-62-8 4-(2-hydroxy-3-(octylamino)propoxy)benzonitrile 
• 1454703-61-7 4-(2-hydroxy-3-(hexylamino)propoxy)benzonitrile 
• 1454703-64-0 4-(2-hydroxy-3-(dodecylamino)propoxy)benzonitrile 
• 1454703-69-5 4-(3-(dodecylamino)-2-hydroxypropoxy)-N-hydroxybenzimidamide 
• 1454703-68-4 4-(3-(decylamino)-2-hydroxypropoxy)-N-hydroxybenzimidamide 
• 1454703-67-3 4-(3-(octylamino)-2-hydroxypropoxy)-N-hydroxybenzimidamide 
• 1454703-66-2 4-(3-(hexylamino)-2-hydroxypropoxy)-N-hydroxybenzimidamide 
• 123955-25-9 4-[3-(Ethylamino)-2-hydroxypropoxy]benzonitrile 
• 137898-84-1 4-<2-hydroxy-3-propoxy>benzonitrile 

Relevant articles and documents

Chemoselective Epoxidation of Allyloxybenzene by Hydrogen Peroxide Over MFI-Type Titanosilicate

The chemoselective synthesis of 2-(phenoxymethyl)oxirane from allyloxybenzene is achieved with over 90 % yield in a sustainable reaction system using titanium-substituted silicalite-1 (TS-1) as a catalyst, hydrogen peroxide (H2O2) as an oxidant, and a mixture of MeOH/MeCN as a solvent at 40 °C. No acid-catalyzed side reactions prompted by the Lewis acidity of the Ti active site in TS-1 are observed. The TS-1 catalyst can also promote the formation of oxiranes from various p-substituted allyloxybenzenes in good yields. The reaction mechanism is investigated through the reaction with other allyloxy compounds. The results, which are supported by DFT calculations, indicate that an active species of Ti peroxides formed from the reaction of TS-1 with H2O2 selectively oxidizes the allyloxybenzene to 2-(phenoxymethyl)oxirane.

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The present invention relates generally to compounds that inhibit the binding of menin and MLL or MLL fusion proteins and methods of use thereof. In particular embodiments, the present invention provides compositions comprising piperidine-containing compounds and methods of use thereof to inhibit the interaction of menin with MLL oncoproteins (e.g., MLL1, MLL2, MLL-fusion oncoproteins), for example, for the treatment of leukemia, solid cancers, diabetes, and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, MLL-PTD and/or menin.

A new synthesis of sultams from amino alcohols

The base-mediated cyclization of N,O-dimesylate derivatives of cyclic and acyclic amino alcohols provides a simple access to five- and six-member sultams: isothiazolidine-1,1-dioxides and thiazinane-1,1-dioxides respectively.