38840-05-0Relevant articles and documents
ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES
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Paragraph 0236; 0237, (2016/11/17)
Disclosed are a compound including a ligand L_A of chemical formula I, and a preparation and a device containing the compound of the chemical formula I. In the compound having a ligand L_A of chemical formula I, R^1 is monosubstitution, bisubstitution, or non-substitution, R^2 is monosubstitution, bisubstitution, trisubstituion, tetrasubstitution, or non-substitution, R is selected from hydrogen, deuterium, alkyl, cycloalkyl, and combination of the same, and R^1 and R^2 are dependently selected from hydrogen, deuterium, alkyl, cycloalkyl, aryl, and combination of the same, a random adjacent substituent of R^2 is randomly connected to form a condensed ring, the ligand L_A is coordinately bonded to metal M, and the ligand L_A is randomly connected to another ligand, and includes a tridentate, tetradentate, pentadentate, and hexadentate.COPYRIGHT KIPO 2015
Synthesis and spectroscopic comparison of the eight methyl-2,3′-bipyridyls and identification of a hoplonemertine alkaloid as 3-methyl-2,3′-bipyridyl
Kem, William R.,Rocca, James,Garraffo, H. Martin,Spande, Thomas F.,Daly, John W.,Soti, Ferenc
experimental part, p. 1025 - 1041 (2009/12/26)
The pyridyl ring is frequently found in natural products and drugs. While bipyridyls have served as useful scaffolds for development of industrial and pesticidal chemicals, their biological properties are still not well understood. Only 2,3--bipyridyl, of the six isomeric bipyridyls, has been reported as a natural product in tobacco plants and in a hoplonemertine marine worm, Amphiporus angulatus (Aa), which uses its pyridyl alkaloid-rich venom to paralyze its crustacean prey and chemically defend itself against predators. Here we report for the first time the synthesis and spectroscopic properties of all eight possible methyl 2,3′-bipyridyl isomers and use this data to identify a trace alkaloidal constituent of Aa as 3-methyl-2,3′-bipyridyl. This is only the second reported instance of a methyl-bipyridyl being found as a natural product, the first being the tobacco alkaloid 5-methyl-2,3′-bipyridyl.
SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER
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Page/Page column 98, (2010/02/12)
Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic acetylcholine receptor (nAChR). Also disclosed are pharmaceutical compositions comprising a compound of the invention, as well as methods of using the pharmaceutical compositions for treating or preventing a disease or disorder associated with nicotine-ingestion, or a disease or disorder amenable to treatment by selective modulation of nAChRs.